The paternal age effect describes the influence that a father's age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do. This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man's lifetime.
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Achondroplasia (dwarfism); craniofacial disorders such as Apert syndrome and Crouzon Syndrome; mental retardation of unknown etiologies; autism; bipolar disorder; and 25% of schizophrenia cases are correlated with advanced paternal age.
Other disorders related to advanced paternal age are:
- Wilms' tumor
- Thanatophoric dysplasia
- Retinitis pigmentosa
- Osteogenesis imperfecta type IIA
- Acrodysostosis
- Fibrodysplasia ossificans progressiva
- Aniridia
- Bilateral retinoblastoma
- Multiple exostoses
- Marfan syndrome
- Lesch-Nyhan syndrome
- Pfeiffer syndrome
- Wardenburg syndrome
- Treacher Collins syndrome
- Soto's basal cell nevus
- Cleidocranial dysostosis
- Polyposis coli
- Oculodentodigital syndrome
- Costello syndrome
- Progeria
- Recklinghausen's neurofibromatosis
- Tuberous sclerosis
- Polycystic kidney disease
- Hemophilia A
- Duchenne muscular dystrophy
- Athetoid cerebral palsy
- Dystonic cerebral palsy
- Congenital hemiplegia
- Down syndrome
- Bipolar disorder
See also
References
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- Tarin JJ, Brines J, Cano A (1998). "Long-term effects of delayed parenthood". Human Reproduction 13 (9): 2371–6. doi:. http://humrep.oxfordjournals.org/cgi/reprint/13/9/2371.
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External links
- MeSH Paternal+age
- University of Queensland news = Time is not on the side of older dads
- CBC podcast - Quirks & Quarks
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