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Paul Karrer

 
Scientist: Paul Karrer

Swiss chemist (1889–1971)

Karrer, the son of a Moscow dentist, was educated at the University of Zurich where he obtained his PhD. After working in Frankfurt he returned to the University of Zurich in 1918, where he served as professor of chemistry until his retirement in 1959.

He began his research career working on the chemistry of plant pigments. Although Karrer tackled a wide variety of such pigments his most significant result was his determination, by 1930, of the structure of carotene, the yellow pigment found in such vegetables as carrots. By 1931 he had also worked out the structure of vitamin A and synthesized it. The similarity between the two molecules did not escape Karrer's attention and it was later shown that vitamin A is derived from the breakdown of carotene in the liver. Karrer went on to synthesize vitamin B2 (riboflavin) in 1935 and vitamin E (tocopherol) in 1938.

In 1937 Karrer was awarded, along with Norman Haworth, the Nobel Prize for chemistry for his work on the “constitution of carotenoids, flavins, and vitamins A and B.” Karrer was the author of a respected textbook, Lehrbuch der organischen Chemie (1927; Textbook of Organic Chemistry).

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Food and Nutrition: Paul Karrer
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(1889-1971) Russian-born chemist; first to isolate vitamins A and K, first to synthesize vitamins B2 and E; Nobel Prize 1937.

Music Encyclopedia: Paul Karrer
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(b Zante, 12 May 1829; d there, April 1896). Greek composer. For his two operas on Greek subjects, Marcos Botsaris (1857) and Kyra Frosyni (1869), he may be regarded (with Xyandas) as the initiator of authentic Greek opera.



 
Columbia Encyclopedia: Paul Karrer
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Karrer, Paul, 1889-1971, Swiss organic chemist, Ph.D. Univ. of Zürich, 1911. From 1912 to 1918, Karrer was a chemist at the Georg Speyer Haus, Frankfurt-am-Main. He left in 1919 to become professor of chemistry and director of the Chemical Institute at the Univ. of Zürich, where he remained until his retirement in 1953. Karrer won the 1937 Nobel Prize in Chemistry with Norman Haworth for his investigations on carotenoids, flavins, and vitamins A and B2. Karrer is credited with being the first to isolate vitamins A and K and to synthesize vitamins B2 and E. His most significant accomplishment was elucidating the structure of carotene, the yellow pigment found in carrots and other orange and yellow vegetables.
Wikipedia: Paul Karrer
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Paul Karrer

Born 21 April 1889(1889-04-21)
Moscow, Russia
Died 18 June 1971 (aged 82)
Zürich, Switzerland
Nationality Switzerland
Fields Chemistry
Institutions Universität Zürich
Alma mater Universität Zürich
Known for Vitamins
Notable awards Nobel Prize for Chemistry (1937)

Paul Karrer (21 April 1889 – 18 June 1971) was a Swiss organic chemist best known for his research on vitamins. He and Walter Haworth won the Nobel Prize for Chemistry in 1937.

Contents

Biography

Early years

Karrer was born in Moscow, Russia to Paul Karrer and Julie Lerch, both Swiss nationals. In 1892 Karrer's family returned to Switzerland where he was educated at Wildegg and at the grammar school in Lenzburg, Aarau, where he matriculated in 1908. He studied chemistry at the University of Zurich under Alfred Werner and after gaining his Ph.D. in 1911, he spent a further year as assistant in the Chemical Institute. He then took a post as chemist with Paul Ehrlich at the Georg Speyer Haus, Frankfurt-am-Main. In 1919 he became Professor of Chemistry and Director of the Chemical Institute.

Research

Karrer's early research concerned complex metal compounds but his most important work has concerned plant pigments, particularly the yellow carotenoids. He elucidated their chemical structure showed that some of these substances are transformed in the body into vitamin A. His work led to the establishment of the correct constitutional formula for beta-carotene, the chief precursor of vitamin A; the first time that the structure of a vitamin or provitamin had been established. George Wald worked briefly in Karrer's lab while studying the role of vitamin A in the retina. Later, Karrer confirmed the structure of ascorbic acid (vitamin C) and extended his researches into the vitamin B2 and E. His important contributions to the chemistry of the flavins led to identification of lactoflavin as part of the complex originally thought to be vitamin B2.

Karrer published many papers, and received many honours and awards, including the Nobel Prize in 1937. His textbook Lehrbuch der Organischen Chemie (Textbook of Organic Chemistry) was published in 1927, went through thirteen editions, and was published in seven languages.

Personal life

Karrer was married to Helena Froelich in 1914 and had two sons. He died 1971 at the age of 82 in Zürich.

References

  • Shampo (2000). "Paul Karrer--research on vitamins". Mayo Clinic proceedings. Mayo Clinic 75 (4): 328. PMID 10761480. 
  • Isler (1978). "Paul Karrer, 21 April 1889--18 June 1971". Biographical memoirs of fellows of the Royal Society. Royal Society (Great Britain) 24: 245–321. doi:10.1098/rsbm.1978.0009. PMID 11615740. 
  • Schmid (1972). "Paul Karrer, 1889-1971". Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften 28 (5): 367–70. PMID 4566692. 
  • Roche (1972). "Paul Karrer (1889-1971)". Bulletin de l'Academie nationale de medecine 156 (4): 89–92. PMID 4565808. 
  • Karrer (1953). "Crystallized 3-carboxamide-N1-D-ribosidopyridinium bromide and related compounds". Biochimica et biophysica acta 12 (1-2): 51–5. PMID 13115412. 

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Copyrights:

Scientist. A Dictionary of Scientists. Copyright © Market House Books Ltd 1993, 1999, 2003. All rights reserved.  Read more
Food and Nutrition. A Dictionary of Food and Nutrition. Copyright © 1995, 2003, 2005 by A. E. Bender and D. A. Bender. All rights reserved.  Read more
Music Encyclopedia. The Concise Grove Dictionary of Music. Copyright © 1994 by Oxford University Press, Inc.. All rights reserved.  Read more
Columbia Encyclopedia. The Columbia Electronic Encyclopedia, Sixth Edition Copyright © 2003, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/ Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Paul Karrer" Read more