The Peptidyl transferase is an aminoacyltransferase (EC 2.3.2.12) as well as the primary enzymatic function of the ribosome which forms peptide links between adjacent amino acids using tRNAs during the translation process of protein biosynthesis.
Peptidyl transferase activity is carried out by the ribosome.
- In Bacteria, the 50S (23S component) ribosome subunit contains the peptidyl transferase component and acts as a ribozyme.
- In eukaryotic cells, the 60S (28S component) ribosome subunit contains the peptidyl transferase component and acts as the ribozyme.
Peptidyl transferases are not limited to translation but there are relatively few enzymes with this function.
Antibiotic target
The following protein synthesis inhibitors target peptidyl transferase:
See also
References
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Protein biosynthesis: translation (prokaryotic, eukaryotic) |
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| Ribosomal proteins |
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Archaeal
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aIF1 aIF2 aIF5 aIF6
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eIF1 ( AX, AY, 1B)
eIF2 (α, β, γ)
eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6)
eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H)
eIF5 (A, A2, 5B)
eIF6
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Other
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