perosixome proliferator activated receptor (PPARγ)

RET protooncogene mutation which encodes a transmembrane receptor with tyrosine kinase activity has been linked to PTC and activating mutation of BRAF Activating point mutations in the RAS oncogene has been found in patients with follicular adenoma and carcinoma and p53 mutation and PAX8-peroxisome proliferator-activated receptor gamma [PPAR γ1] and PIK3CA mutations and amplifications and PTEN mutations in the PI3K/Akt signaling pathway and beta-catenin mutations

ACTOS is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. ACTOS decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma .

A generic version of Actos has been approved by the FDA. However, this does not mean that the product will necessarily be commercially available .

generic available From AUG - 12 .

Better to write Lipidemia. Hope you are talking about excess amount of fat in the blood called Hyperlipidemia. Hyperlipidemia . There are many types Ia, Ib, II, III, IV, V types. Statins are useful for the treatment of type II, dietary modification is the initial approach, but many patients require treatment with statins (HMG-CoA reductase inhibitors) to reduce cardiovascular risk. If the triglyceride level is markedly raised, fibrates (peroxisome proliferator-activated receptor-alpha agonists) may be preferable due to their beneficial effects.

Cold receptors would be activated, maybe causing you to shiver.