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Pharmacogenomics

 
AnswerNote: Pharmacogenomics
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Pharmacogenomics is the study of how an individual's genetic inheritance (his/her genome) affects the body's response to drugs. The term "pharmacogenomics" comes from the words pharmacology and genomics and is thus the intersection of pharmaceuticals and genetics.

Pharmacogenomics holds the promise that drugs might one day be tailor-made for individuals and adapted to each person's own genetic makeup. Environment, diet, age, lifestyle, and state of health all can influence a person's response to medicines, but understanding an individual's genetic makeup is thought to be the key to creating personalized drugs with greater efficacy and safety.

Pharmacogenomics combines traditional pharmaceutical sciences such as biochemistry with annotated knowledge of genes, proteins, and single nucleotide polymorphisms.

Last updated: June 21, 2004.

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Biology Q&A: What is pharmacogenomics?
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Pharmacogenomics is the use of DNA technology to develop new drugs and optimize current drug treatment to individual patients. For example, the interaction of a drug with a specific protein can be studied and then compared to a cell in which a genetic mutation has inactivated that protein. Its potential is to tailor drug therapy to an individual's genome, a tailoring that could reduce adverse drug reactions and increase the efficacy of drug treatment.

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Wikipedia: Pharmacogenomics
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Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimise drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.[1]

Pharmacogenomics is the whole genome application of pharmacogenetics, which examines the single gene interactions with drugs.

See also

References

  1. ^ "Guidance for Industry Pharmacogenomic Data Submissions" (PDF). U.S. Food and Drug Administration. March 2005. http://www.fda.gov/cder/guidance/6400fnl.pdf. Retrieved 2008-08-27. 

Pharmacogenomics is the study of a patient's genes to predict response to drugs and hence select the right drug and the right quantity.

FDA have Released a List of Genomic Biomarkers Predictive of Drug Interactions in August 1, 2008 http://www.fda.gov/cder/genomics/genomic_biomarkers_table.htm

External links

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