I could certainly be wrong, but my recollection is that a phase locked loop
is a universal detector for Frequency and Phase modulation, and is quite
insensitive to Amplitude modulation.
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Yes, you can use a C18 column and methanol as a mobile phase with fluorescence detector. Fluorescence detector is generally used as it can detect the presence of compounds at a very low concentration.
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A non coherent detector is a type of device that does not need a
receiver carrier to be phase locked to a transmitter carrier. A
coherent detector demodulates signals.
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We can quantitatively analyse pregabalin on hplc with uv
detector, wavelength will be 210 n.m. and mobile phase will be 5 %
acetonitrile. standard & sample solution preparation should be
in mobile phase.
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To use the PLL (Phase Lock Loop) as FM detector, you need to
know the Free-running frequency.