phosphofructokinase

[PHOSPHO- + FRUCTO(SE) + KINASE.]

An enzyme that plays a key part in glycolysis, accelerating the conversion of a phosphate of glucose to a phosphate of fructose. PFK activity is particularly important in power events, such as sprinting, during which glycolysis must take place several hundred times faster than at rest. The concentration of PFK is higher in muscle fibres of sprinters than those of endurance athletes. The limited ability of children to perform anaerobic activities may be due to their relatively low concentration of PFR. Those with McArdle's disease (a deficiency in phosphofructokinase or phosphorylase) have an impaired ability to utilize intramuscular glycogen as an energy substrate.

Fructose 6-phosphate

Fructose-1,6-bisphosphate

Fructose-2,6-bisphosphate

"PFK" redirects here. PFK (Poulet Frit Kentucky) is also the name for KFC in French-speaking Quebec, Canada. For the Polish hip-hop group, see Paktofonika.

Phosphofructokinase is a kinase enzyme that acts upon Fructose 6-phosphate. There are two types:

• Phosphofructokinase 1 - converts to fructose-1,6-bisphosphate
• Phosphofructokinase 2 - converts to fructose-2,6-bisphosphate

See also

• Phosphofructokinase deficiency
• PFKM

External links

• MeSH Phosphofructokinases

This biochemistry article is a stub. You can help Wikipedia by expanding it.

v • d • e Transferases: Phosphotransferases/kinases (EC 2.7) 2.7.1: OH acceptor Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD+ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Bruton's tyrosine · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase 2.7.2: COOH acceptor Phosphoglycerate · Aspartate 2.7.3: N acceptor Creatine 2.7.4: PO4 acceptor Phosphomevalonate · Adenylate · Nucleoside-diphosphate 2.7.6: P2O7 Ribose-phosphate diphosphokinase · Thiamine pyrophosphokinase 2.7.7: nucleotidyl- Polymerase DNA polymerase DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme · Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase RNA nucleotidyltransferase RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase Other Recombinase (Integrase) · RNase PH · UDP-glucose pyrophosphorylase · Galactose-1-phosphate uridylyltransferase · Transposase 2.7.8: other phos. N-acetylglucosamine-1-phosphate transferase 2.7.10-11: protein Tyrosine · Serine/threonine-specific 2.7.12: dual-specificity Dual-specificity kinase · Mitogen-activated protein kinase kinase 2.7.13 protein-histidine Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

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