This is a small structure, about the size of a pea, situated approximately in the centre of the head. Because it is one of the few obviously unpaired structures in the brain, the seventeenth-century French philosopher René Descartes (1596-1650) suggested that it was the seat of the soul, mediating subjective experience and intervening in the machinery of the brain in situations of free will and moral choice. In reality, the pineal gland is essentially part of the visual system. In mammals it responds indirectly to light because it receives messages along fibres from nerve cells of the suprachiasmatic nucleus of the hypothalamus, which themselves receive signals from the eye via fibres of the optic nerve. The suprachiasmatic nucleus is the body's major rhythm-generating centre — the heart of the body clock. In lower vertebrates the pineal gland is itself a ‘clock’ and its cells respond directly to light. The main output of the pineal gland is the ‘darkness’ hormone melatonin, which is normally made at night. Melatonin, by the duration of its secretion, serves to indicate to the body both darkness and the length of the night. This signal is used to regulate the timing of biological rhythms.
— Josephine Arendt
Bibliography
- Arendt, J. (1995) Melatonin and the mammalian pineal gland. Chapman and Hall, London, New York
See also biological rhythms; body clock; hypothalamus; mind-body problem.
