Piperacillin
Drug Info:
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Piperacillin
Chemical formula:
Piperacillin Sodium Solution for injection
What is this medicine?
PIPERACILLIN (pi PER a sil in) is a penicillin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•bleeding problems
•kidney disease
•salt restricted diet
•an unusual or allergic reaction to piperacillin, other penicillin or cephalosporin antibiotics, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
This medicine is for infusion into a vein or injection deep into a muscle. It is usually given by a health care professional in a hospital or clinic setting.
If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medicine?
•aspirin and aspirin-like drugs
•certain antibiotics given by injection
•medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin
•methotrexate
•probenecid
•vecuronium used for sleep during surgery
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Your doctor will monitor your condition and blood work as needed.
Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.
This medicine can interfere with some urine glucose tests. If you use such tests, talk with your health care professional.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•difficulty breathing, wheezing
•dizzy, drowsy
•fever, chills
•pain or difficulty passing urine
•red spots on the skin
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•seizures
•unusual bleeding, bruising
•unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•diarrhea
•headache
•nausea, vomiting
•pain, swelling and irritation at the injection site
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Related Videos:
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Piperacillin
Oxford A-Z of Medicinal Drugs:
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piperacillin
A broad-spectrum penicillin that is active against Pseudomonas and Proteus bacteria. It is used for the treatment of systemic and local infections (such as infected wounds or burns) and respiratory, urinary-tract, abdominal, or skin infections. Given by injection or infusion in combination with tazobactam, it is available on prescription only.
Side effects, precautions, and interactions with other drugs:
see benzylpenicillin.
Proprietary preparation:
Tazocin (combined with tazobactam).
| pioglitazone, pindolol, pimozide | |
| piperazine, pipotiazine palmitate, piracetam |
Saunders Veterinary Dictionary:
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piperacillin
An extended-spectrum semisynthetic penicillin active against a wide variety of gram-negative, gram-positive and anaerobic bacteria.
Mosby's Dental Dictionary:
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piperacillin sodium
n
A semisynthetic extended spectrum penicillin active against a wide variety of grampositive and gram-negative bacteria.
Wikipedia on Answers.com:
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Piperacillin
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|---|---|
| Systematic (IUPAC) name | |
| (2S,5R,6R)-6-{[(2R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-phenyl-acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | |
| Clinical data | |
| AHFS/Drugs.com | Consumer Drug Information |
| Pregnancy cat. | B |
| Legal status | POM (UK) ℞-only (US) |
| Routes | IV, IM |
| Pharmacokinetic data | |
| Bioavailability | not absorbed orally |
| Metabolism | largely not metabolised |
| Half-life | 36–72 minutes |
| Excretion | 20% in bile, 80% unchanged in urine |
| Identifiers | |
| CAS number | 61477-96-1  |
| ATC code | J01CA12 |
| PubChem | CID 43672 |
| IUPHAR ligand | 422 |
| DrugBank | DB00319 |
| ChemSpider | 39798 |
| UNII | 9I628532GX |
| KEGG | D08380 |
| ChEBI | CHEBI:8232 |
| ChEMBL | CHEMBL702 |
| Chemical data | |
| Formula | C23H27N5O7S |
| Mol. mass | 517.555 g/mol |
| SMILES | eMolecules & PubChem |
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 (what is this?) (verify) |
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Piperacillin is an extended spectrum beta-lactam antibiotic of the ureidopenicillin class. It is normally used together with a beta-lactamase inhibitor, notably in the combination piperacillin/tazobactam.
Administration
Piperacillin is not absorbed orally, and must therefore be given by intravenous or intramuscular injection. It has been shown that the bacteriocidal actions of the drug do not increase with concentrations of piperacillin higher than 4-6xMIC, which means that the drug is concentration-independent in terms of its actions. Piperacillin has instead shown to offer higher bacteriocidal activity when its concentration remains above the MIC for longer periods of time (50% time>MIC showing the highest activity). This higher activity (present in continuous dosing) has not been directly linked to clinical outcomes, but however does show promise of lowering possibility of resistance and decreasing mortality.[1]
References
- ^ Lau W, Mercer D, Itani K, et al. (2006). "Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection". Antimicrob Agents Chemother 50 (11): 3556–61. doi:10.1128/AAC.00329-06. PMC 1635208. PMID 16940077. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635208.
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Copyrights:
Oxford A-Z of Medicinal Drugs
Market University Press. © 2000, 2003, 2010 An A-Z of Medicinal Drugs. All rights reserved.
Read more
Saunders Veterinary Dictionary
Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.
Read more
Mosby's Dental Dictionary
Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.
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