Pleurisy is inflammation of the lining of the lungs and chest (the pleura) that leads to chest pain (usually sharp) when you take a breath or cough.

Pleuritis; Pleuritic chest pain

Pleurisy may develop when you have lung inflammation due to infections such as pneumonia or tuberculosis. It is often a sign of a viral infection of the lungs. This inflammation also causes the sharp chest pain of pleurisy.

It may also occur with:

• Asbestos-related disease
• Certain cancers
• Chest trauma
• Pulmonary embolus
• Rheumatic diseases

The main symptom of pleurisy is pain in the chest. This pain most likely occurs when you take a deep breath in or out, or cough. Some people feel the pain in the shoulder.

Deep breathing, coughing, and chest movement makes the pain worse.

Pleurisy can cause fluid to collect inside the chest cavity. This can make breathing difficult and may cause the following symptoms:

• Bluish skin color (cyanosis)
• Coughing
• Shortness of breath
• Rapid breathing (tachypnea)

When you have pleurisy, the normally smooth lining of the lung (the pleura) become rough. They rub together with each breath, and may produce a rough, grating sound called a "friction rub." The health care professional can hear this sound with the stethoscope, or by placing an ear against the chest.

The health care provider may perform the following tests:

• CBC
• Thoracentesis
• Ultrasound of the chest
• X-ray of the chest

The health care provider can remove fluid in the lungs by thoracentesis and check it for signs of infection.

Treatment depends on what is causing the pleurisy. Bacterial infections are treated with antibiotics. Some bacterial infections require a surgical procedure to drain all the infected fluid.

Viral infections normally run their course without medications. Patients often can control the pain of pleurisy with acetaminophen or anti-inflammatory drugs such as ibuprofen.

Recovery depends on what is causing the pleurisy.

• Breathing difficulty
• Collapsed lung due to thoracentesis
• Complications from the original illness

Call your health care provider if you have symptoms of pleurisy. If you have breathing difficulty or your skin turns blue, seek immediate medical care.

Early treatment of bacterial respiratory infections can prevent pleurisy.

Celli BR. Diseases of the diaphgragm, chest wall, pleura, and mediastinum. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 100.