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Portal Runner happened in 2001.
Portal Runner was created on 2001-09-10.
1) Hepatic Portal Vein
2) Renal Portal System
3) Hypothalamic-Hypophyseal Portal System
not so sure about number 2 :P
Foreign Exchange - 2004 The Portal 1-1 was released on:
USA: 5 November 2004
it took me about 9 hours, but i have played portal 1.