The preferred topical anesthetic for ophthalmic use. Called also proxymetacaine hydrochloride.
Proxymetacaine
| Veterinary Dictionary: proparacaine |
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| Wikipedia: Proxymetacaine |
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Proxymetacaine
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| Systematic (IUPAC) name | |
| 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate | |
| Identifiers | |
| CAS number | 5875-06-9 (HCl) |
| ATC code | S01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H26N2O3 |
| Mol. mass | 294.389 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Plasma |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Topical (eye drops) |
Proxymetacaine (INN) or proparacaine (USAN), trade names Alcaine, Ak-Taine, and others, is a topical anesthetic drug of the amino ester group. It is indicated for use as an ophthalmic anesthetic (as eye drops) to reduce pain and discomfort during procedures involving the eye. Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%.
Mechanism of action
Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Proxymetacaine". Read more |
