The poison in a Pyracantha is in such tiny amounts that being
pricked by a thorn would not cause any problems.
The above may be true but I have found on several occasions when
pruning our Pyracantha that the almost inevitable pricks by the
amazingly sharp thorns will often leave me with a very sore and red
finger or arm. This goes away after 2 or 3 days. This is possibly
due to the minute amounts of cyanide in the plants.