The quinolones are a group of antibiotics. They are considered
broad spectrum antibiotics in that they can treat a wide variety of
things, and are broken down into four generations based on their
specific sensitivities:
First generation quinolones have a wide gram positive spectrum,
but the gram negative coverage is pretty narrow. They are not used
much anymore because they tend to have toxicity issues.
Second generation quinolones have a little wide gram negative
spectrum, but a little narrower gram positive.
Third generation quinolones are like second generation but can
also work against Staph.
Fourth generation quinolones are like third generation but have
a wider gram positive coverage and can also treat anaerobes.