Dictionary:
ra·nit·i·dine (rə-nĭt'ĭ-dēn')  |
An antagonist for one of two types of histamine receptors occurring on the surfaces of cells, especially gastric cells, that inhibits gastric acid secretion and is used primarily in the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease.
[rani- (shortening and alteration of furanyl, containing furan : FURAN + -YL) + perhaps T(H)IO- + D(IAM)INE.]
| 5min Related Video: ranitidine |
| Dental Dictionary: ranitidine |
trade name: Zantac, Zantac EFFERdose, Zantac GEL-dose, Zantac 75; drug class: H2 histamine receptor antagonist; action: inhibits histamine at H2-receptor sites in parietal cells, which inhibit gastric acid secretion; uses: duodenal ulcers, gastric ulcers, hypersecretory conditions, gastroesophageal reflux disease.
| Drug Info: Ranitidine |
Brand names: Wal-ZanZantac®
Chemical formula:
Ranitidine Hydrochloride Oral tablet
What is this medicine?
RANITIDINE is a type of antihistamine that blocks the release of stomach acid. It is used to treat stomach or intestinal ulcers. It can relieve ulcer pain and discomfort, and the heartburn from acid reflux.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•kidney disease
•liver disease
•porphyria
•an unusual or allergic reaction to ranitidine, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. If you only take this medicine once a day, take it at bedtime. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medicine?
•atazanavir
•delavirdine
•gefitinib
•glipizide
•ketoconazole
•midazolam
•procainamide
•propantheline
•triazolam
•warfarin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Tell your doctor or health care professional if your condition does not start to get better or gets worse. You may need to take this medicine for several days as prescribed before your symptoms get better. Finish the full course of tablets prescribed, even if you feel better.
Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can lengthen the time it will take for ulcers to heal. Cigarettes and alcohol can also make acid reflux or heartburn worse.
If you need to take an antacid you should take it at least 1 hour before or 1 hour after this medicine. This medicine will not be as effective if taken at the same time as an antacid.
If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional at once. You may have a bleeding ulcer.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•agitation, nervousness, depression, hallucinations
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breast enlargement in both males and females
•breathing problems
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•unusual bleeding or bruising
•unusually weak or tired
•vomiting
•yellowing of the skin or eyes
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•constipation or diarrhea
•dizziness
•headache
•nausea
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Veterinary Dictionary: ranitidine |
A histamine H2-blocking agent used in the treatment of gastric ulceration and chronic hypertrophic gastritis.
| Wikipedia: Ranitidine |
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Ranitidine
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| Systematic (IUPAC) name | |
| N-(2-[(5-(dimethylaminomethyl)furan- 2-yl)methylthio]ethyl)- N-methyl- 2-nitroethene- 1,1-diamine | |
| Identifiers | |
| CAS number | 66357-35-5 |
| ATC code | A02BA02 |
| PubChem | 3001055 |
| DrugBank | APRD00254 |
| ChemSpider | 571454 |
| Chemical data | |
| Formula | C13H22N4O3S |
| Mol. mass | 314.4 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 39 to 88% |
| Metabolism | Hepatic |
| Half life | 2–3 hours |
| Excretion | 30–70% Renal |
| Therapeutic considerations | |
| Licence data | |
| Pregnancy cat. |
B1(AU) |
| Legal status |
Pharmacy Only (S2)(AU) OTC(US) P/POM (UK) |
| Routes | Oral, IV |
 (what is this?) (verify) |
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Ranitidine hydrochloride (INN) (pronounced /rəˈnɪtɨdiːn/) is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). Ranitidine is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. Ranitidine is currently marketed under the brand name Zinetac or Zantac (not to be confused with Xanax).
Contents |
Certain preparations of ranitidine are available over the counter (OTC) in various countries. In the United States, 75 mg and 150 mg tablets are available OTC. In Australia, packs containing 7 or 14 doses of the 150 mg tablet are available in supermarkets, small packs of 150 mg and 300 mg tablets are Schedule 2 Pharmacy Medicines. Larger doses and pack sizes still require a prescription.
Outside of the United States, ranitidine is combined with bismuth (which acts as a mild antibiotic) as a citrate salt (ranitidine bismuth citrate, Tritec), to treat Helicobacter pylori infections. This combination is usually given with clarithromycin, an antibiotic.
Ranitidine was developed by Glaxo in an effort to match the success of Smith, Kline & French (prior to the merger of the two companies into GlaxoSmithKline) with the first histamine H2-receptor antagonist cimetidine. Ranitidine was the result of a rational drug-design process using what was by then a fairly refined model of the histamine H2-receptor and quantitative structure-activity relationships (QSAR).
Glaxo refined the model further by replacing the imidazole-ring of cimetidine with a furan-ring with a nitrogen-containing substituent, and in doing so developed ranitidine. Ranitidine was found to have a far-improved tolerability profile (i.e. fewer adverse drug reactions), longer-lasting action, and ten times the activity of cimetidine. Ranitidine has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers Famotidine and Nizatidine have no CYP450 significant interactions.[1]
Ranitidine was introduced in 1981 and was the world's greatest-selling prescription drug by 1988. It has since largely been superseded by the even more effective proton pump inhibitors, with omeprazole becoming the biggest-selling drug for many years. When omeprazole and ranitidine were compared in a study of 144 people with severe inflammation and erosions or ulcers of the esophagus, 85 percent ot those treated with omeprazole healed within eight weeks, compared to 50 percent of those given ranitidine. In addition, the omeprazole group reported earlier relief of heart burn symptoms.[2]
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This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
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Copyrights:
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 | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved. Read more |
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| Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Ranitidine". Read more |
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