Robert Koch

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Robert (Heinrich Hermann) Koch

Library of Congress

[b. Klausthal-Zellerfeld, Hanover, Germany, December 11, 1843, d. Baden-Baden, Germany, May 27, 1910]

A founder of the science of bacteriology, Koch devised a procedure in 1876 to demonstrate that the bacterium Bacillus anthracis causes anthrax, a disease of animals that can also be transmitted to humans. It was the first time that a particular bacterium was shown to be the cause of a particular disease. Koch also discovered the bacteria that cause tuberculosis (Mycobacterium tuberculosis) and cholera (Vibrio cholerae). He developed improved methods for staining bacteria and introduced the use of gelatin and, later, agar as growing media for bacterial colonies.

Robert Koch (1843–1910) was one of the greatest bacteriologists who ever lived. He was born in Klausthal, in what is now Germany, and educated at Göttingen, where he studied medicine before going into practice. His first achievement was to isolate and identify the anthrax bacillus (1876). In 1882 he isolated and identified the tubercle bacillus (Mycobacterium tuberculosis), and in 1883, while leading an expedition to Egypt and India, he identified the bacterium that causes cholera (Vibrio cholerae). In 1885 Koch was appointed professor of hygiene and bacteriology at the University of Berlin, and in 1891 he became director of the Institute for Infectious Diseases in Berlin. He studied bacterial diseases not only in humans but also in animals, and identified, among others, the cause of rinderpest, the lethal and economically important cattle plague of Africa.

His work was facilitated by many of the techniques he and his associates developed to isolate bacteria and grow them on culture media in the laboratory. Koch published many papers and books and fostered the development of a whole generation of bacteriologists and medical scientists in other fields, not only in his native Germany but from many other nations as well. With Jakob Henle he developed the Henle-Koch postulates, four basic criteria that are required for proof that a micro-organism caused a disease: (1) the organism can be isolated in every case of the disease; (2) it can be cultivated in pure culture; (3) cultured organisms can induce the disease in experimental animals; and (4) the organism can be recovered from the infected experimental animals. Robert Koch was awarded the Nobel Prize in medicine in 1905, a fitting capstone to his distinguished career.

(SEE ALSO: Anthrax; Cholera; Henle, Jacob; Tuberculosis)

— JOHN M. LAST

(b Rudolstadt, 10 Oct 1749; d there, 19 March 1816). German theorist. After serving as a violinist (and later Konzertmeister) at the Rudolstadt court, he devoted himself to writing. His principal work, Versuch einer Anleitung zur Composition (1782 - 93), the most comprehensive composition treatise of the Classical era, was influential especially for its detailed treatment of musical form. He also wrote an important dictionary of musical terms, Musikalisches Lexikon (1802).

The German physician and bacteriologist Heinrich Hermann Robert Koch (1843-1910) devised many bacteriological techniques and established the bacterial causes of a number of infectious diseases.

Robert Koch was born at Clausthal, Hanover, on Dec. 11, 1843, the third of a family of 13. He enrolled in medical classes at the University of Göttingen in 1862, and in 1866 he passed the qualifying examinations. He spent some time in clinical study in Berlin but did not wish to engage in general practice. When the Franco-Prussian War broke out in 1870, he was accepted for service in the army.

In 1872 Koch was appointed district medical officer at Wollstein. That year he began his bacteriological research with a microscope his wife gave him. Following the publication of some of his early findings, Koch was appointed to the Imperial Health Office at Berlin in 1880. In 1885 he became professor of hygiene at the University of Berlin and director of the newly founded Institute of Hygiene at the university. In 1891 the Institute for Infectious Diseases was founded for him, and he acted as director until 1904.

Foundations of Bacteriology

One of the first diseases Koch studied was anthrax, an ancient and highly fatal cattle disease. While the bacillus associated with anthrax had been identified by C. J. Davaine in 1868, no significant advances had been made in the prevention or treatment of this disease. In addition, it had been noted that cattle became infected not only from other cattle but from grazing in fields where infected cattle had been kept years before. This observation seemed to discredit the bacillus as a causative agent.

Koch, attracted by the frequency of occurrence and the unusual behavior of anthrax, set out to solve the problem. He arrived at several valid conclusions: under certain conditions the anthrax bacillus forms spores which are viable but which remain dormant for several years, thus explaining the mystery of the infected fields; the integrity of the bacillus is maintained even though the infection passes through several generations of mice; and the cattle are usually inoculated with the bacillus by eating fodder soiled with the numerous organisms in excreta of infected animals.

In arriving at these conclusions, Koch acted on certain principles that are often referred to as "Koch's postulates": to prove that an organism is the specific cause of any disease, it must be present invariably in all cases; it must be isolated in pure culture; and when a susceptible host is inoculated with a live culture, the disease must be reproduced. Koch for the first time irrefutably proved the manner in which anthrax arises and is transmitted. Thus the foundations of medical bacteriology were laid, and rational principles of hygiene and epidemiology in man and animals were established.

Studies of Tuberculosis

In 1881 Koch announced his discovery of the tubercle bacillus. He isolated the organisms from tubercular lesions and grew them successfully in pure cultures. This was a remarkable achievement at that time, for the bacillus is fastidious in its food requirements and grows very slowly. However, Koch experienced several disappointments with his studies of tuberculosis. Having found that tuberculosis in cattle was produced by an organism which differed from that of the human variety in both cultural characteristics and virulence, he formed the opinion that human tuberculosis was not transmitted to cattle, and bovine tuberculosis could not be transmitted to man. This was completely disproved by the British Royal Commission on Tuberculosis in 1911. Koch's other disappointment was associated with tuberculin, a protein component extracted from a killed culture of tubercle bacilli. It has proved a valuable diagnostic tool, as Koch suggested, but it has no effect as a curative agent, although Koch originally offered it to the public as a treatment.

Another major discovery which revolutionized bacteriology was Koch's use of culture media which could be rendered solid, for example, blood serum by heating, meat broth by adding gelatin or agar, a product derived from seaweed. The advantage of growing bacteria on solid media is that isolated colonies are obtained which often have a characteristic appearance, thereby enabling one to select pure cultures easily. Thus it can be readily understood how within some 10 years a whole series of specific pathogens - including the causal agents of cholera, typhoid fever, and diphtheria; common pyogenic bacteria which cause suppuration in wounds; and varieties of intestinal flora - were isolated by Koch and others.

Almost every medical bacteriologist of the next generation was trained by Koch. His help was constantly in demand by the governments of his and other countries with microbiological problems, human or veterinary. He was always a hygienist who never forgot the essential importance of clean air, food, water, and soil in protecting populations from infective diseases. As a pure bacteriologist, he remained unequaled. His techniques are the basis of all modern bacteriological methods. In 1905 he received the Nobel Prize. He died in Baden-Baden on May 27, 1910.

Further Reading

There are two studies of Koch in German: Karl Wezel, Robert Koch (1912), and Bruno Heymann, Robert Koch (1932). In English, he is treated at length in Paul de Kruif, Microbe Hunters (1926), and lago Galdston, Progress in Medicine: A Critical Review of the Last Hundred Years (1940).

Robert Koch
Born	11 December 1843(1843-12-11) Clausthal, Kingdom of Hanover
Died	27 May 1910 (aged 66) Baden-Baden, Grand Duchy of Baden
Fields	Microbiology
Institutions	Imperial Health Office, Berlin, University of Berlin
Alma mater	University of Göttingen
Doctoral advisor	Friedrich Gustav Jakob Henle
Known for	Discovery bacteriology Koch's postulates of germ theory Isolation of anthrax, tuberculosis and cholera
Notable awards	Nobel Prize in Medicine (1905)

For other persons named Robert Koch, see Robert Koch (disambiguation).

Heinrich Herman Robert Koch (11 December 1843 – 27 May 1910) was a German physician. He became famous for isolating Bacillus anthracis (1877), the Tuberculosis bacillus (1882) and the Vibrio cholera (1883) and for his development of Koch's postulates. He was awarded the Nobel Prize in Physiology or Medicine for his tuberculosis findings in 1905. He is considered one of the founders of microbiology—he inspired such major figures as Paul Ehrlich and Gerhard Domagk.

Contents 1 Biography 2 Honors and awards 3 References 4 External links

Biography

Heinrich Hermann Robert Koch was born in Clausthal, Germany as the son of a mining official. He studied medicine under Friedrich Gustav Jakob Henle at the University of Göttingen and graduated in 1866. He then served in the Franco-Prussian War and later became district medical officer in Wollstein (Wolsztyn), Prussian Poland. Working with very limited resources, he became one of the founders of bacteriology, the other major figure being Louis Pasteur.

After Casimir Davaine showed the direct transmission of the anthrax bacillus between cows, Koch studied anthrax more closely. He invented methods to purify the bacillus from blood samples and grow pure cultures. He found that, while it could not survive outside a host for long, anthrax built persisting endospores that could last a long time.

These endospores, embedded in soil, were the cause of unexplained "spontaneous" outbreaks of anthrax. Koch published his findings in 1876, and was rewarded with a job at the Imperial Health Office in Berlin in 1880. In 1881, he urged the sterilization of surgical instruments using heat.

In Berlin, he improved the methods he used in Wollstein, including staining and purification techniques, and bacterial growth media, including agar plates (thanks to the advice of Angelina and Walther Hesse) and the Petri dish, named after its inventor, his assistant Julius Richard Petri. These devices are still used today. With these techniques, he was able to discover the bacterium causing tuberculosis (Mycobacterium tuberculosis) in 1882 (he announced the discovery on 24 March). Tuberculosis was the cause of one in seven deaths in the mid-19th century.

In 1883, Koch worked with a French research team in Alexandria, Egypt, studying cholera. Koch identified the vibrio bacterium that caused cholera, though he never managed to prove it in experiments. The bacterium had been previously isolated by Italian anatomist Filippo Pacini in 1854, but his work had been ignored due to the predominance of the miasma theory of disease. Koch was unaware of Pacini's work and made an independent discovery, and his greater preeminence allowed the discovery to be widely spread for the benefit of others. In 1965, however, the bacterium was formally renamed Vibrio cholera Pacini 1854.

In 1885, he became professor of hygiene at the University of Berlin, then in 1891 he was made Honorary Professor of the medical faculty and Director of the new Prussian Institute for Infectious Diseases (eventually renamed as the Robert Koch Institute), a position from which he resigned in 1904. He started traveling around the world, studying diseases in South Africa, India, and Java.

Probably as important as his work on tuberculosis, for which he was awarded a Nobel Prize (1905), are Koch's postulates, which say that to establish that an organism is the cause of a disease, it must be:

• found in all cases of the disease examined
• prepared and maintained in a pure culture
• capable of producing the original infection, even after several generations in culture
• retrievable from an inoculated animal and cultured again.

After Koch's success the quality of his own research declined (especially with the fiasco over his ineffective TB cure "tuberculin"), although his pupils found the organisms responsible for diphtheria, typhoid, pneumonia, gonorrhoea, cerebrospinal meningitis, leprosy, bubonic plague, tetanus, and syphilis, among others, by using his methods.

Robert Koch died on 27 May 1910 from a heart-attack in Baden-Baden, aged 66.

Honors and awards

Monument to Robert Koch on his name square in Berlin

The crater Koch on the Moon is named after him. The Robert Koch Prize and Medal were created to honour Microbiologists who make groundbreaking discoveries or who contribute to global health in a unique way. The now-defunct Robert Koch Hospital at Koch, Missouri (south of St. Louis, Missouri), was also named in his honor. A hagiographic account of Koch's career can be found in the 1939 Nazi propaganda film Robert Koch, der Bekämpfer des Todes (The fighter against death), directed by Hans Steinhoff and starring Emil Jannings as Koch.

References

• "Robert Koch and the Institute". Robert Koch Institute. 2004-11-30. http://www.rki.de/cln_011/nn_231522/EN/Content/Institute/History/Robert__Koch.html__nnn=true. Retrieved 2008-05-24. 
• Brock, Thomas D. (1999). Robert Koch: A Life in Medicine and Bacteriology. Washington, D.C.: ASM Press. ISBN 9781555811433. OCLC 39951653. 
• Morris, Robert D (2007). The blue death: disease, disaster and the water we drink. New York: Harper Collins. ISBN 9780060730895. OCLC 71266565. 

External links

• Robert Koch Biography at the Nobel Foundation website
• Robert Koch Biography and bibliography in the Virtual Laboratory of the Max Planck Institute for the History of Science
• original microscope out of the laboratory Robert Koch used in Wollstein (1877)
• microscope objectives as they were used by Robert Koch for his first photos of microorganisms (1877 - 1878)

v • d • e Nobel Laureates in Physiology or Medicine Emil Behring (1901) · Ronald Ross (1902) · Niels Finsen (1903) · Ivan Pavlov (1904) · Robert Koch (1905) · Camillo Golgi / Santiago Ramón y Cajal (1906) · Alphonse Laveran (1907) · Ilya Mechnikov / Paul Ehrlich (1908) · Emil Kocher (1909) · Albrecht Kossel (1910) · Allvar Gullstrand (1911) · Alexis Carrel (1912) · Charles Richet (1913) · Robert Bárány (1914) · Jules Bordet (1919) · August Krogh (1920) · Archibald Hill / Otto Meyerhof (1922) · Frederick Banting / John Macleod (1923) · Willem Einthoven (1924) Complete roster · 1901–1925 · 1926–1950 · 1951–1975 · 1976–2000 · 2001–present

Persondata
NAME	Koch, Robert
ALTERNATIVE NAMES
SHORT DESCRIPTION	German physician and bacteriologist
DATE OF BIRTH	11 December 1843(1843-12-11)
PLACE OF BIRTH	Clausthal, Germany
DATE OF DEATH	1910-05-27
PLACE OF DEATH	Baden-Baden, Germany

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