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rosacea

 

Definition

Rosacea is a skin disease typically appearing in people during their 30s and 40s. It is marked by redness (erythema) of the face, flushing of the skin, and the presence of hard pimples (papules) or pus-filled pimples (pustules), and small visible spider-like veins called telangiectasias. In later stages of the disease, the face may swell and the nose may take on a bulb-like appearance called rhinophyma.

Description

Rosacea produces redness and flushing of the skin, as well as pustules and papules. Areas of the face, including the nose, cheeks, forehead, and chin, are the primary sites, but some people experience symptoms on their necks, backs, scalp, arms, and legs.

The similarity in appearance of rosacea to acne led people in the past to erroneously call the disease acne rosacea or adult acne. Like acne, the skin can have pimples and papules. Unlike acne, however, people with rosacea do not have blackheads.

In early stages of rosacea, people typically experience repeated episodes of flushing. Later, areas of the face are persistently red, telangiectasia appear on the nose and cheeks, as well as inflamed papules and pustules. Over time, the skin may take on a roughened, orange peel texture. Very late in the disorder, a small group of patients with rosacea will develop rhinophyma, which can give the nose a bulb-like look.

Up to one half of patients with rosacea may experience symptoms related to their eyes. Ocular rosacea, as it is called, frequently precedes the other manifestations on the skin. Most of these eye symptoms do not threaten sight, however. Telangiectasia may appear around the borders of the eyelid, the eyelids may be chronically inflamed, and small lumps called chalazions may develop. The cornea of the eye, the transparent covering over the lens, can also be affected, and in some cases vision will be affected.

— Richard H. Camer



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Dictionary: ro·sa·ce·a   (rō-zā'shē-ə) pronunciation
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n.
A chronic dermatitis of the face, especially of the nose and cheeks, characterized by a red or rosy coloration, caused by dilation of capillaries, and the appearance of acnelike pimples. Also called acne rosacea.

[New Latin (acne) rosācea, rose-colored (acne), from Latin, feminine of rosāceus, made of roses. See rosaceous.]


Dental Dictionary:

acne rosacea

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n

A condition of the facial skin typically indicated by blushing, swelling, and the appearance of broken blood vessels in a “spider web” pattern.

Definition

Rosacea is a skin disease typically appearing in persons during their 30s and 40s. It is marked by redness (erythema) of the face, flushing of the skin, and the presence of hard pimples (papules) or pus-filled pimples (pustules) as well as small, visible spider-like veins called telangiectasia. In later stages of the disease, the face may swell and the nose may take on a bulbous appearance, a condition called rhinophyma.

Description

Rosacea produces redness and flushing of the skin, as well as pustules and papules. Areas of the face, including the nose, cheeks, forehead, and chin, are the primary sites, but some persons experience symptoms on their necks, backs, scalp, arms, and legs. It is a common disease that afflicts one out of every 20 Americans.

The similarity in appearance of rosacea to acne led people in the past to erroneously call the disease acne rosacea or adult acne. Like acne, the skin can have pimples and papules. Unlike acne, however, persons with rosacea do not have blackheads.

Causes & Symptoms

There is no known specific cause of rosacea. A history of redness and flushing precedes the disease in most patients. The consensus among many experts is that multiple factors may lead to an overreaction of the facial blood vessels, which triggers flushing. Over time, persistent episodes of redness and flushing leave the face continually inflamed. Pimples and blood-vessel changes follow.

Unidentified genetic factors may also come into play because 40% of rosacea sufferers have a family member who has rosacea. The disease is more common in women and in persons with light skin and fair hair. It may be more common in persons with a Celtic, English, Scandinavian, Swedish, Welsh, Polish, Lithuanian, or Balkan background.

Because certain antibiotics are useful in the treatment of rosacea, some researchers suspect a bacterium or other infectious agent may be the cause. One of the newest suspects is a bacterium called Helicobacter pylori, which has been implicated in causing stomach ulcers. The evidence supporting this suspicion is mixed.

Other investigators have observed that a particular parasite, the microscopic mite Demodex folliculorum, can be found on areas of the skin affected by rosacea. However, this mite can also be detected in the skin of persons who do not have the disease. It is likely that this mite does not cause rosacea, but merely aggravates it.

Rosacea may be caused by factors such as a deficiency of B-complex vitamins or hydrochloric acid (HCl) in the stomach. Some researchers suspect that yeast may cause rosacea.

In early stages of rosacea, patients typically experience repeated episodes of flushing. Later, areas of the face are persistently red and telangiectasia, as well as inflamed papules and pustules, appear on the nose and cheeks. Over time, the skin may take on a roughened, orange-peel texture. Very late in the disorder, a small group of patients with rosacea will develop rhinophyma, which can give the nose a reddened, bulbous appearance. The late actor W.C. Fields was affected with this condition. Men are three times more likely than women to develop rhinophyma.

Up to one-half of patients with rosacea may experience symptoms related to their eyes. Ocular rosacea, as it is called, frequently precedes the other manifestations on the skin. Telangiectasia may appear around the borders of the eyelid, the eyelids may be chronically inflamed, and small lumps called chalazions may develop. The cornea of the eye (the transparent covering over the lens) can also be affected, and in some cases vision will be affected. Most of these eye symptoms do not threaten sight, however.

Diagnosis

Diagnosis of rosacea is made by the presence of clinical symptoms. There is no specific test for the disease. Episodes of persistent flushing, redness (erythema) of the nose, cheeks, chin, and forehead, accompanied by pustules and papules are hallmarks of the disease. A dermatologist (skin disease specialist) will attempt to rule out a number of other diseases that have similar symptoms. Acne vulgaris is perhaps the disorder most commonly mistaken for rosacea, but acne patients do not have redness and spider-like veins. Blackheads and cysts are seen in acne patients, but not in those with rosacea.

Other diseases that produce some of the same symptoms as rosacea include perioral dermatitis, seborrheic dermatitis, and systemic lupus erythematosus.

Treatment

There is no cure for rosacea, but alternative and complementary treatments can be helpful in reducing the skin irritation and number of outbreaks associated with the disease. Green-tinted makeup can mask the redness associated with rosacea. Because rosacea may cause psychological distress, psychotherapy or support groups can be an important component of treatment.

Patients should avoid using skin care products that contain alcohol, witch hazel, peppermint, menthol, eucalyptus oil, or clove oil. Skin care products should be fragrance-free and have a smooth, non-grainy consistency. Men can shave with an electric razor to lessen skin irritation on the face.

Persons who are treated for rosacea with antibiotics over a long period are more prone to yeast infections. Long-term antibiotic use can decrease normal bacteria populations and increase the number of yeast. Eating a yeast-free diet (eliminating breads and other yeast products and sugars) can help to restore normal bacteria to the body.

Identifying Food Triggers

Certain foods are known to trigger an outbreak of rosacea. Although individual triggers vary, the following foods may aggravate rosacea: hot spices (pepper, paprika, and cayenne), marinated meat, soy sauce, vanilla, vinegar, red plums, peas, lima and navy beans, sharp cheeses, cider, Asian food dishes, canned fish products, processed beef and pork, chocolate, tomatoes, citrus fruit, alcohol, and hot beverages. Nitrates, sulfites, and certain drugs can also trigger outbreaks. Food allergies can also cause rosacea. The three foods that most often cause food allergies are wheat products, sugar, and dairy products.

Rosacea patients should keep a food diary to identify the specific foods that trigger rosacea outbreaks. Outbreaks can occur hours—or as long as a day—after the offending food has been eaten. The patient should stop eating a suspect food for a few months to observe the severity of the rosacea symptoms. If the rosacea improves, the patient can then eat a small amount of the offending food to confirm whether it triggers an outbreak. Once a rosacea trigger food is identified, it can be eliminated from the patient's diet.

Other Treatments

Applying liquid-filled cold packs, a washcloth soaked in ice-cold water, or a compress of cold milk and ice-cold water to the neck and face can relieve flushing. Sucking on ice chips can also help relieve flushing. A cold compress of chamomile tea can soothe irritated skin. Applying ice to the face may feel good but it can cause frostbite, which would worsen the reddening.

Some practitioners advocate gentle circular massage for several minutes daily to the nose, cheeks, and fore-head. However, controlled studies on the effectiveness of this technique are lacking.

A deficiency of hydrochloric acid (HCl) in the stomach may be a cause of rosacea, and supplementation with HCl capsules (taken after meals) may bring relief in some cases.

Hypnosis may reduce stress, promote healthful behavior, and control bad habits. Hypnotherapy is especially useful in treating skin disease that can be triggered by emotions, including rosacea. As a complementary therapy, hypnosis has been shown to improve rosacea, especially the flushing component.

Nutritionists recommend eating more dark green vegetables such as kale, broccoli, asparagus, and spinach. These foods, and others that contain high levels of vitamins A and C, bioflavonoids, and beta-carotene, can improve rosacea by increasing capillary strength and boosting the immune system. Apple juice and dark grape juice drunk at room temperature between meals can help persons with rosacea.

A deficiency of B-complex vitamins can lead to rosacea. Vitamin E's antioxidant properties can help prevent skin damage. Zinc can speed wound healing. Omega-3 and omega-6 fatty acid deficiencies can lead to dry, irritated skin, which can worsen rosacea. Omega-3 fatty acids can be found in flaxseed oil, cod liver oil, salmon, mackerel, and herring. Omega-6 fatty acid is found in evening primrose oil.

Allopathic Treatment

The mainstay of treatment for rosacea is oral antibiotics. These appear to work by reducing inflammation in the small blood vessels and structure of the skin, not by destroying bacteria that are present. One of the more widely used oral antibiotics is tetracycline. In many patients, antibiotics are effective against the papules and pustules that can appear on the face. But antibiotics appear to be less effective against the background redness, and they have no effect on telangiectasia. Patients frequently take a relatively high dose of antibiotics until their symptoms are controlled, and then they slowly reduce their daily dose to a level that just keeps their symptoms in check. Other oral antibiotics used include erythromycin and minocycline.

Some patients are concerned about long-term use of oral antibiotics. For them, a topical agent applied directly to the face may be tried in addition to an oral antibiotic or in its place. Topical antibiotics are also useful for controlling the papules and pustules of rosacea, but do not control the redness, flushing, and telangiectasias. The newest of these topical agents is metronidazole gel, which can be applied twice daily.

Vitamin A derivatives called retinoids also appear useful in the treatment of rosacea. An oral retinoid called isotretinoin, which is used in severe cases of acne, reduces the pustules and papules in severe cases of rosacea that do not respond to antibiotics. Isotretinoin must be taken with care, particularly in women of childbearing age, because the drug is known to cause birth defects.

Topical vitamin A compounds may have a role in the treatment of rosacea. Accumulating evidence suggests that topical isotretinoin and topical azelaic acid can reduce the redness and pimples.

For later stages of the disorder, a surgical procedure may be needed to improve the appearance of the skin. To remove the telangiectasias, a dermatologist may use an electrocautery device to apply an electrical current to the blood vessel. This procedure cuts off the blood to the blood vessel, effectively destroying it and eliminating its appearance as a red line. Special lasers, called tunable dye lasers, can selectively destroy these tiny blood vessels. A variety of surgical techniques can be used to improve the shape and appearance of a bulbous nose. Surgeons may use a scalpel or laser to remove excess tissue from the nose and restore a more natural appearance.

Expected Results

The prognosis is good for controlling symptoms of rosacea and improving the appearance of the face. Many people require lifelong treatment and achieve good results. There is no known cure for the disorder.

Prevention

Rosacea cannot be prevented, but once its is correctly diagnosed, outbreaks can be treated and repeated episodes can be limited. Patients can reduce outbreaks of rosacea by following this advice:

  • Use mild soaps and cleansers. Avoiding anything that irritates the skin is a good preventive measure for persons with rosacea. Astringents and alcohol should be avoided.
  • Learn what triggers flushing. Reducing factors in the diet and environment that cause flushing of the face is another good preventive strategy. The specific things that provoke flushing vary considerably from person to person and it usually takes some trial and error to figure these out.
  • Cover the face. Limiting exposure of the face to excesses of heat and cold can also help. A sunscreen with a skin protection factor (SPF) of 15 or greater, used daily, can reduce rosacea outbreaks and limit the damage the sun causes to the skin and small blood vessels. Protective clothing (hats in the summer and scarves or ski masks in the winter) can reduce the skin's exposure to sun and cold temperatures.

Resources

Books

Helm, Klaus F., and James G. Marks. Atlas of Differential Diagnosis in Dermatology. New York: Churchill Livingstone, 1998.

Macsai, Marian S., et al. "Acne Rosacea." In Eye and Skin disease. Edited by Mark J. Mannis, et al. Philadelphia: Lippincott-Raven, 1996.

Periodicals

Jansen, Thomas, and Gerd Plewig. "Rosacea: Classification and Treatment." Journal of the Royal Society of Medicine 90 (March 1997): 144–150.

Litt, Jerome Z. "Rosacea: How to Recognize and Treat an Age-Related Skin Disease." Geriatrics 52 (November 1997): 39+.

Shenefelt, Philip D. "Hypnosis in Dermatology." Archives of Dermatology 136 (March 2000): 393–399.

Thiboutot, Diane M. "Acne Rosacea." American Family Physician 50 (December 1994): 1691–1697.

Organizations

American Academy of Dermatology. 930 N. Meacham Road, PO Box 4014, Schaumburg, IL 60168-4014. (847) 330-0230. http://www.aad.org.

National Rosacea Society. 800 S. Northwest Highway, Suite 200, Barrington, IL 60010. (888) 662-5874. http://www.rosacea.org.

Other

"Rosacea." MotherNature.com. http://www.mothernature.com/library/books/homeseniors/rosacea.asp.

[Article by: Belinda Rowland]

Wikipedia:

Rosacea

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Rosacea
Classification and external resources

An Old Man and His Grandson, by Domenico Ghirlandaio shows skin damage from end-stage rosacea[1]
ICD-10 L71.
ICD-9 695.3
DiseasesDB 96
MedlinePlus 000879
eMedicine derm/377
MeSH D012393

Rosacea (pronounced /roʊˈzeɪʃɪə/) is a chronic condition characterized by facial erythema (redness).[2] Pimples are sometimes included as part of the definition.[3] Unless it affects the eyes, it is typically a harmless cosmetic condition. Treatment, if wanted, usually involves topical medications to reduce inflammation.

It primarily affects Caucasians of mainly northwestern European descent and has been nicknamed the 'curse of the Celts' by some in Britain and Ireland, but can also affect people of other ethnicities. Rosacea affects both sexes, but is almost three times more common in women. It has a peak age of onset between 30 and 60.

Rosacea typically begins as redness on the central face across the cheeks, nose, or forehead, but can also less commonly affect the neck, chest, ears, and scalp.[4] In some cases, additional symptoms, such as semi-permanent redness, telangiectasia (dilation of superficial blood vessels on the face), red domed papules (small bumps) and pustules, red gritty eyes, burning and stinging sensations, and in some advanced cases, a red lobulated nose (rhinophyma), may develop.

Contents

Types of rosacea

Zones

There are four identified rosacea subtypes[5] and patients may have more than one subtype present[6]:176:

  1. Erythematotelangiectatic rosacea: Permanent redness (erythema) with a tendency to flush and blush easily. It is also common to have small blood vessels visible near the surface of the skin (telangiectasias) and possibly burning or itching sensations.[citation needed]
  2. Papulopustular rosacea: Some permanent redness with red bumps (papules) with some pus filled (pustules) (which typically last 1–4 days); this subtype can be easily confused with acne.
  3. Phymatous rosacea: This subtype is most commonly associated with rhinophyma, an enlargement of the nose. Symptoms include thickening skin, irregular surface nodularities, and enlargement. Phymatous rosacea can also affect the chin (gnatophyma), forehead (metophyma), cheeks, eyelids (blepharophyma), and ears (otophyma).[7] Small blood vessels visible near the surface of the skin (telangiectasias) may be present.
  4. Ocular rosacea: Red, dry and irritated eyes and eyelids. Some other symptoms include foreign body sensations, itching and burning.

Variants of rosacea

There are a number of variants of rosacea including:[8]:689

Causes

Cathelicidins

Richard L. Gallo and colleagues recently noticed that patients with rosacea had elevated levels of the peptide cathelicidin[9] and elevated levels of stratum corneum tryptic enzymes (SCTEs). Antibiotics have been used in the past to treat rosacea but they may only work because they inhibit some SCTEs.[10]

Intestinal bacteria

Intestinal bacteria may play a role in causing the disease. A recent study subjected patients to a hydrogen breath test to determine the occurrence of small intestinal bacterial overgrowth (SIBO). It was found that patients had a significantly higher incidence than controls (47% v. 5%, p<0.001).

SIBO-positive patients were then given a 10-day course of rifaximin, an antibiotic that does not leave the digestive tract and therefore cannot reach the skin or circulation. 96% of patients experienced a complete remission of rosacea symptoms that lasted at least 9 months. These patients were also negative when retested for bacterial overgrowth. In the 4% of patients that had experienced relapse, it was found that bacterial overgrowth had returned, and a second course of antibiotic treatment again produced temporary remission.[11]

In another study, it was found that some rosacea patients that tested SIBO-negative using a hydrogen breath test, were still positive when using a methane breath test instead. These patients did not respond to rifaximin, as found in the previous study, but experienced clearance of rosacea symptoms and normalization of breath tests following administration of the antibiotic metronidazole, which is effective at targeting methanogenic anaerobic bacteria, such as would be found in the intestines.[12]

These results suggest diverse strains of intestinal bacteria may be responsible for mediating these effects in patients. It may also explain the improvement in symptoms experienced by some patients when given a reduced carbohydrate diet.[13] Such a diet would reduce the potential for bacterial fermentation and thereby reduce bacterial populations in the intestines. Although controversial, it should be noted that a reduced carbohydrate diet is likely to be more consistent with the diet our ancestors would have eaten prior to the use of agriculture and that modern patterns of carbohydrate consumption could be an important environmental cause of bacterial overgrowth in some patients.

Demodex mites

Studies of rosacea and demodex mites have revealed that some people with Rosacea have increased numbers of the mite, especially those with steroid induced rosacea.[14] When large numbers are present they may play a role along with other triggers. On other occasions Demodicidosis (Mange) is a separate condition that may have "rosacea-like" appearances.[15]

Other causes

Triggers that cause episodes of flushing and blushing play a part in the development of rosacea. Exposure to temperature extremes can cause the face to become flushed as well as strenuous exercise, heat from sunlight, severe sunburn, stress, anxiety, cold wind, and moving to a warm or hot environment from a cold one such as heated shops and offices during the winter. There are also some food and drinks that can trigger flushing, including alcohol, food and beverages containing caffeine (especially, hot tea and coffee), foods high in histamines and spicy food. It should be noted that foods high in histamine (red wine, aged cheeses, yogurt, beer, cured pork products such as bacon, etc.) can even cause persistent facial flushing in those individuals without rosacea due to a separate condition, histamine intolerance.

Certain medications and topical irritants can quickly trigger rosacea. Some acne and wrinkle treatments that have been reported to cause rosacea include microdermabrasion and chemical peels, as well as high dosages of isotretinoin, benzoyl peroxide, and tretinoin. Steroid induced rosacea is the term given to rosacea caused by the use of topical or nasal steroids. These steroids are often prescribed for seborrheic dermatitis. Dosage should be slowly decreased and not immediately stopped to avoid a flare up.

A survey by the National Rosacea Society of 1,066 rosacea patients showed which factors affect the most people:[16]

  • Sun exposure 81%
  • Emotional stress 79%
  • Hot weather 75%
  • Wind 57%
  • Heavy exercise 56%
  • Alcohol consumption 52%
  • Hot baths 51%
  • Cold weather 46%
  • Spicy foods 45%
  • Humidity 44%
  • Indoor heat 41%
  • Certain skin-care products 41%
  • Heated beverages 36%
  • Certain cosmetics 27%
  • Medications 15%
  • Medical conditions 15%
  • Certain fruits 13%
  • Marinated meats 10%
  • Certain vegetables 9%
  • Dairy products 8%

Diagnosis

Most people with rosacea have only mild redness and are never formally diagnosed or treated. There is no single, specific test for rosacea.

In many cases, simple visual inspection by a trained person is sufficient for diagnosis. In other cases, particularly when pimples or redness on less-common parts of the face are present, a trial of common treatments is useful for confirming a suspected diagnosis.

The disorder can be confused with, and co-exist with acne vulgaris and/or seborrhoeic dermatitis. The presence of rash on the scalp or ears suggests a different or co-existing diagnosis as rosacea is primarily a facial diagnosis, although it may occasionally appear in these other areas.

Treatments

Treating rosacea varies from patient to patient depending on severity and subtypes. A subtype-directed approach to treating rosacea patients is recommended to dermatologists.[17] Mild cases are often not treated at all, or are simply covered up with normal cosmetics.

While medications often produce a temporary remission of redness within a few weeks, the redness typically returns shortly after treatment is suspended. Long-term treatment, usually one to two years, may result in permanent control of the condition for some patients.[citation needed] Lifelong treatment is often necessary, although some cases resolve after a while and go into a permanent remission.

Alternative medicine has cited that an acidic diet contributes to rosacea, and have turned to nutrition as a way to lessen the effects of rosacea through a diet that counters the toxic effects of acidity. A suggested alkaline diet includes foods that contribute to alkalinity: vegetables (carrots, spinach), almonds, soups and some juices, lower sugar fruits, salads and omega oils, as well as plenty of pure water (2-3 liters per day, preferably alkalized by lemon juice drops).

In a study by El-Shazly et al (2004)[18] rosacea patients were treated with daily 1/3 diluted camphor oil with glycerol and 500 mg metronidazole for fifteen days, with successful outcomes and no adverse effects. While this study does not prove that camphor oil is effective (it could be that metronidazole, or metrogel, alone was sufficient), camphor oil can be used without side effects. Be careful with the use of camphor oil, however, as it can irritate the skin. Also, use sparingly, as camphor has been reported to cause reversible hepatotoxicity in extreme cases.[19][20]

Behavior

Trigger avoidance can help reduce the onset of rosacea but alone will not normally cause remission for all but mild cases. It is sometimes recommended that a journal be kept to help identify and reduce food and beverage triggers.[21]

Because sunlight is a common trigger, avoiding excessive exposure to sun is widely recommended. Some people with rosacea benefit from daily use of a sunscreen; others opt for wearing hats with broad brims.

People who develop infections of the eyelids must practice frequent eyelid hygiene. Daily, gentle cleansing of the eyelids with diluted baby shampoo or an over-the-counter eyelid cleaner and applying warm (but not hot) compresses several times a day is recommended.[citation needed]

A recent publication discusses how managing pre-trigger events such as prolonged exposure to cool environments can directly influence warm room flushing.[22]

Medications

Oral tetracycline antibiotics (tetracycline, doxycycline, minocycline) and topical antibiotics such as metronidazole are usually the first line of defense prescribed by doctors to relieve papules, pustules, inflammation and some redness.[23] Topical azelaic acid such as Finacea (15%) or Skinoren (20%) may help reduce inflammatory lesions, bumps and papules. Oral antibiotics may help to relieve symptoms of ocular rosacea. If papules and pustules persist, then sometimes isotretinoin can be prescribed.[24] Isotretinoin has many side effects and is normally used to treat severe acne but in low dosages is proven to be effective against papulopustular and phymatous rosacea.

The treatment of flushing and blushing has been attempted by means of the centrally acting α-2 agonist clonidine, but this is of limited benefit on just this one aspect of the disorder.[25] The same is true of the beta-blockers nadolol and propranolol. If flushing occurs with red wine consumption, then complete avoidance helps. There is no evidence at all that antihistamines are of any benefit in rosacea. However: people with underlying allergies and who respond strongly to foods that are high in histamine or that release a lot of histamine in the body do find sometimes that their flushing symptoms diminish with oral antihistamines (for instance loratadine). Another medication that can help some people with facial flushing and burning is mirtazapine (remeron).

One alternative skin treatment, fashionable in the Victorian and Edwardian eras, was sulphur. Recently sulphur has re-gained some credibility as a safe alternative to steroids and coal tar.[citation needed]

Recently, a clinically-trialled product range combining plant-sourced Methylsulfonylmethane (MSM) and Silymarin has been used to treat rosacea, skin redness and flushing.[26]

Laser

Dermatological vascular laser (single wavelength) or Intense Pulsed Light (broad spectrum) machines offer one of the best treatments for rosacea, in particular the erythema (redness) of the skin.[27] They use light to penetrate the epidermis to target the capillaries in the dermis layer of the skin. The light is absorbed by oxy-hemoglobin which heat up causing the capillary walls to heat up to 70 °C (158 °F) , damaging them, causing them to be absorbed by the body's natural defense mechanism. With a sufficient number of treatments, this method may even eliminate the redness altogether, though additional periodic treatments will likely be necessary to remove newly-formed capillaries.

CO2 lasers can be used to remove excess tissue caused by phymatous rosacea. CO2 lasers emit a wavelength that is absorbed directly by the skin. The laser beam can be focused into a thin beam and used as a scalpel or defocused and used to vaporise tissue. Low level light therapies have also been used to treat rosacea. Photorejuvenation can also be used to improve the appearance of rosacea and reduce the redness associated with it.[28][29][30]

Famous people

Self-conscious about his rosacea, J. P. Morgan hated being photographed.

Famous people with Rosacea include:

See also

References

  1. ^ Koepsell, Thomas (2002). "Domenico Ghirlandaio: An Old Man and His Grandson (ca 1480-1490)". Arch Pediatr Adolesc Med 156: 966. 
  2. ^ rosacea at Dorland's Medical Dictionary
  3. ^ "Glossary - Dermatology - Online Medical Encyclopedia - University of Rochester Medical Center". http://www.urmc.rochester.edu/encyclopedia/content.cfm?pageid=P01903#R. Retrieved 2009-02-21. 
  4. ^ "All About Rosacea". National Rosacea Society. http://www.rosacea.org/patients/allaboutrosacea.php. Retrieved 2008-11-10. 
  5. ^ Wilkin J, Dahl M, Detmar M, Drake L, Liang MH, Odom R, Powell F (2004). "Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea" (PDF reprint). J Am Acad Dermatol 50 (6): 907–12. doi:10.1016/j.jaad.2004.01.048. PMID 15153893. http://www.rosacea.org/grading/gradingsystem.pdf. 
  6. ^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. ISBN 1-4160-3185-5.
  7. ^ Jansen T, Plewig G (1998). "Clinical and histological variants of rhinophyma, including nonsurgical treatment modalities". Facial Plast Surg 14 (4): 241–53. doi:10.1055/s-2008-1064456. PMID 11816064. 
  8. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  9. ^ Yamasaki K, Di Nardo A, Bardan A, et al. (August 2007). "Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea". Nat. Med. 13 (8): 975–80. doi:10.1038/nm1616. PMID 17676051. 
  10. ^ See the August 5, 2007 issue of Nature Medicine for details.
  11. ^ Parodi A,Paolino S,Greco A,Drago F,Mansi C,Rebora A,Parodi AU,Savarino V (May 2008). "Small Intestinal Bacterial Overgrowth in Rosacea: Clinical Effectiveness of Its Eradication". Clin Gastroenterol Hepatol. 6: 759. doi:10.1016/j.cgh.2008.02.054. PMID 18456568. 
  12. ^ http://uegw08.uegf.org/scienpro/abstract_detail.php?navId=139&ss=1814
  13. ^ http://www.bmj.com/cgi/pdf_extract/1/5485/459
  14. ^ Erbagcaronci Z, Özgöztascedili O (June 1998). "The significance of Demodex folliculorum density in rosacea". Int J Dermatol. 37 (6): 421–5. doi:10.1046/j.1365-4362.1998.00218.x. PMID 9646125. 
  15. ^ a b Baima B, Sticherling M (2002). "Demodicidosis revisited". Acta Derm Venereol 82 (1): 3–6. doi:10.1080/000155502753600795. PMID 12013194. 
  16. ^ http://www.rosacea.org/patients/materials/triggersgraph.php
  17. ^ Aaron F. Cohen, MD, and Jeffrey D. Tiemstra, MD (May-June 2002). "Diagnosis and treatment of rosacea". J Am Board Fam Pract. 15 (3): 214–7. PMID 12038728. 
  18. ^ El-Shazly AM, Hassan AA, Soliman M, Morsy GH, Morsy TA. Treatment of human Demodex folliculorum by camphor oil and metronidazole. J Egypt Soc Parasitol. 2004 Apr;34(1):107-16.
  19. ^ Martin D, Valdez J, Boren J, Mayersohn M (Oct 2004). "Dermal absorption of camphor, menthol, and methyl salicylate in humans". J Clin Pharmacol 44 (10): 1151–7.
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