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Rudolf Virchow

 
Britannica Concise Encyclopedia:

Rudolf Carl Virchow


(born Oct. 13, 1821, Schivelbein, Pomerania, Prussia — died Sept. 5, 1902, Berlin) German pathologist, anthropologist, and statesman. In 1847 he cofounded the pathology journal now named for him (Virchows Archiv). He held the first chairs of pathological anatomy at the Universities of Würzburg (1849 – 56) and Berlin (1856 – 1902). In 1861 he was elected to the Prussian Diet and founded the Progressive Party. He coined the terms thrombosis and embolism while disproving the theory that phlebitis causes most diseases. His work supported emerging ideas on cell division and metabolism, pointing out that cell division accounted for the multiplication of cells to form tissues. His rejection of the theory that bacteria cause disease and of Ignaz Semmelweis's advocacy of antisepsis delayed the use of antiseptics. Virchow also founded two anthropological societies and accompanied Heinrich Schliemann to Troy (1879) and Egypt (1888).

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Rudolf Carl Virchow
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[b. Schivelbein, Pomerania (Poland), October 13, 1821, d. Berlin, September 5, 1902]

Virchow's many discoveries include cells in bone and connective tissue; substances, such as myelin; and pathologies, such as embolism and leukemia. In 1855 he published his now-famous aphorism omnis cellula e cellula ("every cell stems from another cell"). He also stated that all diseases involve changes in normal cells--that is, all pathology ultimately is cellular pathology.


Rudolph Virchow (1821–1902) was one of the towering figures of nineteenth-century medicine, pathology, and social reform. He studied medicine in Berlin and taught there for a great part of his life, with interludes in Silesia and Würzburg. His primary field was pathology, to which he made prolific contributions, including the founding in 1847 of Archiv für pathologische Anatomie und Physiologie (known as "Virchow's Archives"), which still survives as a leading journal of pathology. In 1848 he served on a commission to investigate an epidemic of typhus, for which he wrote a penetrating report criticizing the social conditions that fostered the spread of the disease. He had already established a reputation as a crusading social reformer, and this report consolidated that reputation. He has since been identified as much with what came to be called "social medicine" as with his primary specialty of pathology.

Virchow's writings and speeches are full of observations and recommendations about ways to improve people's health by improving their economic and social conditions. He helped to shape the health care reforms introduced in Germany under Otto von Bismarck. He entered politics, serving in the German Reichstag (1880–1893), while also directing the Pathological Institute in Berlin. His prolific writings, while mainly on topics in pathology, included many essays and addresses on social medicine and public health. These writings remain relevant over one hundred years after they were first written. Virchow also contributed substantially to anthropology, paleontology, and archeology.

(SEE ALSO: History of Public Health; Social Medicine; Typhus, Epidemic)

Bibliography

Virchow, R. (1985). Collected Essays on Public Health and Epidemiology, ed. and trans. L. J. Rather. Canton, MA: Science History Publications.

— JOHN M. LAST



Gale Encyclopedia of Biography:

Rudolf Ludwig Carl Virchow

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The German medical scientist, anthropologist, and politician Rudolf Ludwig Carl Virchow (1821-1902) was the founder of the school of "cellular pathology, " which forms the basis of modern pathology.

Rudolf Virchow was born on Oct. 13, 1821, in Schivelbein, the only child of a farmer and city treasurer. In 1839 Virchow entered the Friedrich Wilhelms Institute in Berlin to undertake medical studies in preparation for a career as an army doctor. He came under the strong influence of Johannes Müller, who encouraged many German doctors to use experimental laboratory methods in their medical studies. Virchow received his medical degree in 1843, having already shown a keen interest in pathology.

In 1845, while still working as an intern, Virchow published his first scientific paper. By this year he had committed himself to a research methodology based on a mechanistic understanding of vital phenomena. Medical research, according to Virchow, needed to use clinical observation, experiments on animals, and microscopic examination of human tissues in order to understand how ordinary chemical and physical laws could explain the normal and abnormal phenomena associated with life. He accepted the cell theory as one basic element in this mechanistic understanding of life. In committing himself to this view, he joined a group of radical young medical scientists who were then challenging the dominant vitalism of an older generation.

In 1846 Virchow began to teach courses in pathological anatomy. In 1847 he was appointed to his first academic position with the rank of privatdozent. In the same year he and a colleague, Benno Reinhardt, published the first volume of a medical journal, the Archives for PathologicalAnatomy and Physiology and Clinical Medicine. Virchow continued to edit this journal until his death in 1902.

Virchow's radical political views were clearly shown in 1848, the year of revolution in Germany. Early in the year Virchow presented a report on a typhus epidemic in Upper Silesia in which he recommended that the best way to avoid a repetition of the epidemic would be to introduce democratic forms of government. When the revolution broke out in Berlin, Virchow joined the revolutionaries fighting on the barricades. He threw himself wholeheartedly into the revolution, much to the displeasure of his father. He participated in a number of democratic clubs and helped edit a weekly paper, Die medizinische Reform, which promoted revolutionary ideas in relation to the medical profession.

Virchow's political views led to his suspension by the reestablished conservative government in 1849. The suspension was quickly revoked because of the hostile reaction of the medical fraternity. Later the same year Virchow was appointed professor at the University of Würzburg. Shortly after, he married Rose Mayer, the daughter of a leading German gynecologist.

The chair at Würzburg was the first one in Germany to be devoted to pathological anatomy. During Virchow's 7 years there, the medical school became recognized as one of the best in Europe, largely due to his teaching. He developed his concept of "cellular pathology, " basing his interpretation of pathological processes on the recently formulated cell theory of Matthias Schleiden and Theodor Schwann. In the same period he became joint editor of an annual publication reviewing the year's progress in medical science. This publication later became known as Virchow's Jahresbericht, and he continued to edit it until his death. He also started work in 1854 on his Handbook of Special Pathology and Therapeutics, which became the model for later German "handbooks" in various sciences. Although Virchow's main interest at Würzburg was pathology, he also continued to work in the field of public health and began researches in physical anthropology.

In 1856 Virchow accepted a chair at the University of Berlin on condition that a new building be constructed for a pathological institute. He remained in this position for the rest of his life. From 1859 Virchow renewed his activities in politics. In that year he was elected as a member of the city council, on which he served until his death. On the council he mainly interested himself in matters of public health. In 1861 Virchow was one of the foundation members of the Deutsche Fortschrittpartei and was elected in the same year to the Prussian Diet. He vigorously opposed Bismarck's preparations for war and his "blood and iron" policy of unifying Germany.

In the late 1860s and 1870s Virchow concentrated his attention on anthropology and international medical relations. He was active in numerous international medical congresses during this period and kept a continuing interest in the control and prevention of epidemics.

In 1873 Virchow was elected to the Prussian Academy of Science. All his contributions to this body were in the field of anthropology, mostly concerning physical anthropology and archeology. In his new field as in others he took up the task of editing a leading journal, the Zeitschrift fuer Ethnologie. Virchow's later years continued to be active, especially in relation to his editorial duties. He died on Sept. 5, 1902.

Further Reading

A good selection of Virchow's writings is Disease, Life and Man, translated and introduced by Lelland J. Rather (1958). The best account in English of his life is Erwin H. Ackerknecht, Rudolf Virchow: Doctor, Statesman, Anthropologist (1953).

Additional Sources

Ackerknecht, Erwin Heinz, Rudolf Virchow, New York: Arno Press, 1981, 1953.

Boyd, Byron A., Rudolf Virchow: the scientist as citizen, New York: Garland, 1991.

Letters to his parents, 1839 to 1864, Canton, MA: Science History Publications, U.S.A., 1990.

Virchow, Rudolf (Schivelbein, Pomerania 1821-1902, Berlin), an outstanding pathologist of humble origin, became a university lecturer in 1847 in Berlin, but as a Liberal had to flee abroad (i.e. to South Germany) in 1848 (see Revolutionen 1848-9). He obtained an appointment at Würzburg, and was recalled to Prussia in 1856 as director of the Pathologisches Institut and as professor of pathology at Berlin University. In his field of cellular pathology he made known important general principles as well as making significant discoveries of detail. His most widely known work was Vorlesungen über Pathologie (4 vols., 1858-67). His eminence was recognized abroad as well as at home and in 1892 he received the Copley medal of the Royal Society.

Virchow was also a noted anthropologist and visited the site of Troy with H. Schliemann in 1879, afterwards publishing Zur Landeskunde des Troas (1880) and Alt-trojanische Gräber und Schädel (1882). He remained all his life an active Liberal, founding the Progressive Party (Fortschrittspartei), and was a bitter opponent of Bismarck. He was a member of the Reichstag from 1880 to 1893.

Columbia Encyclopedia:

Rudolf Virchow

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Virchow, Rudolf ('dôlf fĭr'khō), 1821-1902, German pathologist, a founder of cellular pathology. He became professor at the Univ. of Würzburg (1849) and professor and director of the Pathological Institute, Berlin (1856). He contributed to nearly every branch of medical science as well as to anthropology, and he introduced sanitary reforms in Berlin. Virchow was a member of the Prussian lower house and later of the Reichstag (1880-93) and he was a leader of the liberal Progressive party opposed to Bismarck. He founded (1847) the Archiv für pathologische Anatomie und Physiologie und für klinische Medizin and wrote numerous works, including Die Cellularpathologie (1858, tr. 1860).

Bibliography

See E. H. Ackerknecht, Rudolf Virchow (1954).

Wikipedia on Answers.com:

Rudolf Virchow

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Rudolf Carl Virchow

Rudolph Virchow
Born 13 October 1821
Schivelbein, Pomerania, Prussia
Died 5 September 1902 (age 80)
Berlin, German Empire
Nationality German
Fields Medicine
Known for Cellular pathology
Biogenesis
Signature

Rudolph Carl Virchow (13 October 1821 – 5 September 1902) was a German doctor, anthropologist, pathologist, prehistorian, biologist and politician, known for his advancement of public health. Referred to as "the father of modern pathology," he is considered one of the founders of social medicine.

Contents

Life and scientific career

From a farming family, he studied medicine and chemistry in Berlin at the Prussian Military Academy from 1839 to 1843[1] on a scholarship. When he graduated in 1843, he went to serve as Robert Froriep's assistant at the Charité Hospital. The campus where this hospital is located is named after him, the Campus Virchow Klinikum. In 1847, he qualified as a lecturer at the University of Berlin, and he was associated with Benno Reinhardt in founding the Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, world-famous as “Virchow's Archives,” which he edited alone from Reinhardt's death in 1852 until his own.[1]

Virchow is credited with multiple important discoveries. Virchow's most widely known scientific contribution is his cell theory, which built on the work of Theodor Schwann. He is cited as the first to recognize leukemia cells.[2] He was one of the first to accept (and plagiarize[3][4]) the work of Robert Remak, who showed that the origins of cells was the division of preexisting cells.[5] He did not initially accept the evidence for cell division, believing that it only occurs in certain types of cells. When it dawned on him that Remak might be right, in 1855, he published Remak's work as his own, which caused a falling out between the two.[3] This work, Virchow encapsulated in the epigram Omnis cellula e cellula ("every cell originates from another existing cell like it."), which he published in 1858. (The epigram was actually coined by François-Vincent Raspail but popularized by Virchow.)[6] It is a rejection of the concept of spontaneous generation, which held that organisms could arise from non-living matter. It was believed, for example, that maggots could spontaneously appear in decaying meat; Francesco Redi carried out experiments which disproved this notion and coined the maxim Omne vivum ex ovo ("every living thing comes from a living thing" — literally "from an egg"), Virchow (and his predecessors) extended this to state that the only source for a living cell was another living cell.

Another significant credit relates to the discovery, made approximately simultaneously by Virchow and Charles Emile Troisier, that an enlarged left supra-clavicular node is one of the earliest signs of gastrointestinal malignancy, commonly of the stomach, or less commonly, lung cancer. This has become known as Virchow's node and simultaneously Troisier's sign.

Virchow is also known for elucidating the mechanism of pulmonary thromboembolism, coining the term embolism. He noted that blood clots in the pulmonary artery originate first from venous thrombi, stating: "The detachment of larger or smaller fragments from the end of the softening thrombus which are carried along by the current of blood and driven into remote vessels. This gives rise to the very frequent process on which I have bestowed the name of Embolia." Related to this research, Virchow described the factors contributing to venous thrombosis, Virchow's triad.

Furthermore, Virchow founded the medical fields of cellular pathology and comparative pathology (comparison of diseases common to humans and animals). His very innovative work may be viewed as sitting between that of Morgagni whose work Virchow studied, and that of Paul Ehrlich, who studied at the Charité while Virchow was developing microscopic pathology there. One of Virchow's major contributions to German medical education was to encourage the use of microscopes by medical students, and he was known for constantly urging his students to "think microscopically".

Rudolf Virchow, by Hugo Vogel.

Virchow also developed a standard method of autopsy procedure, named for him, and many of his techniques are still used today. More than a laboratory physician, Virchow was an impassioned advocate for social and political reform, stating that "Medicine is a social science, and politics is nothing else but medicine on a large scale. Medicine, as a social science, as the science of human beings, has the obligation to point out problems and to attempt their theoretical solution: the politician, the practical anthropologist, must find the means for their actual solution....The physicians are the natural attorneys of the poor, and social problems fall to a large extent within their jurisdiction." His views are evident in his Report on the Typhus Outbreak of Upper Silesia (1848), where he states that the outbreak could not be solved by treating individual patients with drugs or with minor changes in food, housing, or clothing laws, but only through radical action to promote the advancement of an entire population.[7] He is widely regarded as a pioneer of social medicine,[8] and anthropology.[9]

In 1869, Virchow founded the Society for anthropology, ethnology and prehistory (Gesellschaft für Anthropologie, Ethnologie und Urgeschichte) which was very influential in coordinating and intensifying German archaeological research, and of which he was several times president. In 1879, he made a journey to the site of Troy, described in Beiträge zur Landeskunde in Troas (1879) and Alttrojanische Gräber und Schädel (1882).[1] In 1885, he launched a study of craniometry, which gave surprising results contradictory to contemporary scientific racist theories on the "Aryan race", leading him to denounce the "Nordic mysticism" in the 1885 Anthropology Congress in Karlsruhe. Josef Kollmann , a collaborator of Virchow, stated in the same congress that the people of Europe, be they German, Italian, English or French, belonged to a "mixture of various races," furthermore declaring that the "results of craniology" led to "struggle against any theory concerning the superiority of this or that European race" on others .[10]

In 1861, he was elected a foreign member of the Royal Swedish Academy of Sciences. In 1892, he was awarded the Copley Medal. Among his most famous students was anthropologist Franz Boas, who became a professor at Columbia University.

Virchow died of heart failure. He was buried in the St Matthews Cemetery in Schöneberg, Berlin.

Virchow's tomb in Berlin.

The Society for Medical Anthropology gives an annual award in Virchow's name, Rudolf Virchow Award.

Opposition to Darwinism

Virchow famously delivered an anti-Darwinian lecture on human and primate skulls, in which he emphasized the lack of fossil evidence for a common ancestor of man and ape.

Medical terms named after Virchow

  • Virchow's angle, the angle between the nasobasilar line and the nasosubnasal line.
  • Virchow's cell, a macrophage in Hansen's disease.
  • Virchow's cell theory, "omnis cellula e cellula" - every living cell comes from another living cell.
  • Virchow's concept of pathology, comparison of diseases common to humans and animals.
  • Virchow's disease, leontiasis ossea, now recognized as a symptom rather than a disease.
  • Virchow's gland, Virchow's node.
  • Virchow's Law, during craniosynostosis, skull growth is restricted to a plane perpendicular to the affected, prematurely fused suture and is enhanced in a plane parallel to it.
  • Virchow's line, a line from the root of the nose to the lambda.
  • Virchow's metamorphosis, lipomatosis in the heart and salivary glands.
  • Virchow's method of autopsy, a method of autopsy where each organ is taken out one by one.
  • Virchow's node, the presence of metastatic cancer in a lymph-node in the supraclavicular fossa (root of the neck left of the midline). Also known as Troisier's sign.
  • Virchow's psammoma, psammoma bodies in meningiomas.
  • Virchow-Robin spaces, enlarged perivascular spaces (EPVS) (often only potential) that surround blood vessels for a short distance as they enter the brain.
  • Virchow-Seckel syndrome, a very rare disease also known as "bird-headed dwarfism".
  • Virchow's triad, the classic factors which precipitate venous thrombus formation: endothelial dysfunction or injury, hemodynamic changes and hypercoaguability.

Political career

Rudolf Virchow as a public figure.

Virchow made himself known as a pronounced democrat in the year of revolution, 1848, and his political activity caused the government to remove him (1849) from his position, but he was soon reinstated. He became a member of the Municipal Council of Berlin in 1859, and began his career as a civic reformer. Elected to the Prussian Diet in 1862, he became leader of the Radical or Progressive party; and from 1880 to 1893 he was a member of the Reichstag.[1] He worked to improve the health care conditions for the Berlin citizens, namely working towards modern water and sewer systems. Virchow is also credited with the founding of "Social Medicine", frequently focusing on the fact that disease is never purely biological, but often socially derived or spread.

As a co-founder and member of the liberal party (Deutschen Fortschrittspartei) he was a leading political antagonist of Bismarck. He was opposed to Bismarck’s excessive military budget, which angered Bismarck sufficiently to challenge Virchow to a duel in 1865.[1] There are two versions of this anecdote: in one version, Virchow declined since he considered duel as an uncivilized way to solve a conflict; a second legendary but well documented version in the scientific literature states that Virchow, being entitled to choose the weapons, chose two pork sausages: a cooked sausage for himself and an uncooked one, loaded with Trichinella larvae for Bismark, who declined the proposition as too risky.[11] [12] [13]

One area where he co-operated with Bismarck was in the Kulturkampf, the anti-clerical campaign against the Catholic Church[14] claiming that the anti-clerical laws bore "the character of a great struggle in the interest of humanity".[15] It was during the discussion of Falk’s May Laws (Maigesetze) that Virchow first used the term.[16]

Virchow was respected in Masonic circles,[17] and according to one source[18] may have been a freemason, though no official record of this has been found.

Works

He was a very prolific writer. Some of his works are:

  • Mittheilungen über die in Oberschlesien herrschende Typhus-Epidemie (1848)
  • Vorlesungen über Cellularpathologie in ihrer Begründung auf physiologischer und pathologischer Gewebelehre, his chief work (1859) The 4th edition of this work formed the first volume of Vorlesungen über Pathologie below.
  • Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre. (1858; English translation, 1860) [1]
  • Handbuch der speciellen Pathologie und Therapie, prepared in collaboration with others (1854–76)
  • Vorlesungen über Pathologie (1862–72)
  • Die krankhaften Geschwülste (1863–67)
  • Ueber den Hungertyphus (1868)
  • Ueber einige Merkmale niederer Menschenrassen am Schädel (1875)
  • Beiträge zur physischen Anthropologie der Deutschen (1876)
  • Die Freiheit der Wissenschaft im Modernen Staat (1877)
  • Gesammelte Abhandlungen aus dem Gebiete der offentlichen Medizin und der Seuchenlehre (1879)
  • Gegen den Antisemitismus (1880)

References

  1. ^ a b c d e Wikisource-logo.svg "Virchow, Rudolf". Encyclopedia Americana. 1920. 
  2. ^ Mukherjee, Siddhartha (16 November 2010). The Emperor of All Maladies: A Biography of Cancer. Simon and Schuster. ISBN 978-1-4391-0795-9. http://books.google.com/books?id=5rF_31RVTnMC. Retrieved 6 September 2011. 
  3. ^ a b Rutherford, Dr. Adam (August 2009). "The Cell: Episode 1 The Hidden Kingdom". BBC4. http://www.bbc.co.uk/programmes/b00m5w92. 
  4. ^ Silver, George A. (January 1987). "Virchow, the heroic model in medicine: health policy by accolade". American Journal of Public Health 77 (1): 86. PMC 1646803. PMID 3538915. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1646803. Retrieved 2011-04-04. 
  5. ^ A history of the life sciences, Lois N. Magner, p. 185
  6. ^ Tan SY, Brown J (July 2006). "Rudolph Virchow (1821-1902): "pope of pathology"" (PDF). Singapore Med J 47 (7): 567–8. PMID 16810425. http://www.sma.org.sg/smj/4707/4707ms1.pdf. 
  7. ^ http://www.ajph.org/cgi/content/full/96/12/2102
  8. ^ http://www.ajph.org/cgi/content/full/96/12/2104
  9. ^ Rx for Survival . Global Health Champions . Paul Farmer, MD, PhD | PBS at www.pbs.org
  10. ^ Andrea Orsucci, "Ariani, indogermani, stirpi mediterranee: aspetti del dibattito sulle razze europee (1870-1914), Cromohs, 1998 (Italian)
  11. ^ Schultz, Myron (2008). "Rudolf Virchow". Emerg Infect Dis 14 (9): 1480-1481. 
  12. ^ Isaac Asimov. Treasury of Humor (Mariner Books, 1991, ISBN-13: 978-0395572269, Page 202). 
  13. ^ Cardiff, Robert D; Ward, Jerrold M; Barthold, Stephen W (2008). "‘One medicine—one pathology’: are veterinary and human pathology prepared?". Laboratory Investigation 88: 18-12. 
  14. ^ "This anti-Catholic crusade was also taken up by the Progressives, especially Rudolf Virchow, though Richter himself was tepid in his occasional support." Authentic German Liberalism of the 19th Century by Ralph Raico
  15. ^ "The term came into use in 1873, when the scientist and Prussian liberal statesman Rudolf Virchow declared that the battle with the Roman Catholics was assuming “the character of a great struggle in the interest of humanity.” from Kulturkampf. (2006). Britannica Concise Encyclopedia. Retrieved March 25, 2006, from Encyclopædia Britannica
  16. ^ A leading German school teacher, Rudolf Virchow, characterized Bismarck's struggle with the Catholic Church as a Kulturkampf - a fight for culture - by which Virchow meant a fight for liberal, rational principles against the dead weight of medieval traditionalism, obscurantism, and authoritarianism." from The Triumph of Civilization by Norman D. Livergood and "Kulturkampf \Kul*tur"kampf`\, n. [G., fr. kultur, cultur, culture + kampf fight.] (Ger. Hist.) Lit., culture war; - a name, originating with Virchow (1821 - 1902), given to a struggle between the Roman Catholic Church and the German government" Kulturkampf in freedict.co.uk
  17. ^ "Rizal's Berlin associates, or perhaps the word "patrons" would give their relation better, were men as esteemed in Masonry as they were eminent in the scientific world--Virchow, for example." in JOSE RIZAL AS A MASON by AUSTIN CRAIG, The Builder Magazine, August 1916 - Volume II - Number 8
  18. ^ "It was a heady atmosphere for the young Brother, and Masons in Germany, Dr. Rudolf Virchow and Dr. Feodor Jagor, were instrumental in his becoming a member of the Berlin Ethnological and Anthropological Societies." From Dimasalang: The Masonic Life Of Dr. Jose P. Rizal By Reynold S. Fajardo, 33° by Fred Lamar Pearson, Scottish Rite Journal, October 1998

Further reading

  • Becher, Rudolf Virchow, Berlin, (1891)
  • J. L. Pagel, Rudolf Virchow, Leipzig, (1906)
  • Erwin H. Ackerknecht, Rudolf Virchow: Doctor, Statesman, Anthropologist, Madison, (1953)
  • Virchow, RLK (1978) Cellular pathology. 1859 special ed., 204-207 John Churchill London, UK.
  • The Former Philippines thru Foreign Eyes by Tomás de Comyn at Project Gutenberg, available at Project Gutenburg (co-authored by Virchow with Tomás Comyn, Fedor Jagor, and Chas Wilkes)
  • (1) Rudolf Virchow, Menschen- und Affenschadeh Vortrag gehalten am 18. Febr. 1869 im Saale des Berliner Handwerkervereins. Berlin: Luderitz, (1870)
  • Eisenberg, L. "Rudolf Virchow: the physician as politician" Medicine and War 1986;2(4):243-250.

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