If you're speaking of the church dedicated to San Lorenzo, known as San Lorenzo Fuori le Mura (St. Lawrence outside the walls), the original shrine having been built by the Emperor Constantine in the mid-4th century AD. San Lorenzo Fuori le Mura is located in the Roman suburb of Lazio, the church's address being 3 Piazzale del Verano, Via Tiburtina 00185 Rome, Italy. San Lorenzo is one of the five patriarchal basilicas and one of the seven pilgrimage churches of Rome.
However, if you're talking about San Lorenzo the district, Comune Borgo San Lorenzo, in Florence, Tuscany, that's a different story.