After God came to the Garden where Adam and Eve sinned He, the
LORD God (Yahweh) said to the serpent in v. 15, " And I will put
enmity between you and the woman, and between your seed and her
seed...."
After God cursed the physical serpent, He then turned to the
spiritual serpent, Satan, and cursed him. "your seed", this is the
children of the devil or sinners who will not repent. "and her
seed", this is Jesus the Christ. Jesus is a descendant of Eve.
This portion of Scripture is known as the "first gospel". The
woman's offspring called "HE" is Christ, who will one day defeat
the Serpent (Satan).
Satan was defeated at the death, burial and resurrection of
Jesus from the grave 2000 years ago. Although Satan is still active
today he has been defeated and will someday go to the Lake of Fire
(Revelation 20:10).