Differences: A single stage rocket uses all its fuel in one blast and only has one booster stage while space shuttles and multi stage rockets have more than one rocket. - Difference: A single stage rocket cannot go into space while a space shuttle and a multi stage rocket can
Difference: In a multi stage rocket and space shuttle, there is more that one rocket that burns to lift the payload off the ground. After the Stage has used all its fuel and is no longer burning it drops off the other rockets (stages). In a single stage rocket, all the fuel is used in one stage.
Similarity: Both space shuttles and multi stage rockets add junk into earths orbit. A multi stage rocket carries less weight because it drops the empty stages off after they have fully burned and then starts burning a new stage so that there is less weight to carry for the burning rocket so does a space shuttle; a single stage rocket dose not.
Similarity: Multi stage rockets and space shuttles add space junk into the earths orbit when they enter space.
Wikipedia's Top Contributor; Daxter17 =)
Thanks for the e-mail's about the topics guys!