No one "invented" the pro-oxidant properties of polyphenols. Many polyphenols, it has been observed, are unstable in aqueous solutions (especially those above pH 7.0) and will oxidize to for a phenolic oxidation product as well as hydrogen peroxide (Halliwell, B., 2003. Oxidative strress in cell culture: an under-appreciated problem? FEBS Lett 540, 3-6). This phenomenon has been observed to interfere in enzymatic assays and can be compensated by the addition of catalase, an enzyme which degrades hydrogen peroxide (de Boer, Vincent C.J., 2006 SIRT1 stimulation by polyphenols is affected by their stability and metabolism. Mechanisms of ageing and development 127, 618-627).

Most B-complex supplements are 50-100mg across the board. This is fine, but to ensure a positive reaction to your body try for one that contains the following:

Niacin, not Niacinamide for Vitamin B3. Niacinamide has been shown to suppress SIRT1 function in the body, your body's naturally occurring life-extending enzyme. Niacin dilates capillaries, promoting blood flow to the outer layers of the skin, enhances cognition, and removes cell waste. Non-flush niacin is a no-no. Go for plain old niacin, and embrace the "flush" that it brings. It's good for you.

Also, optimal B-12 intake is between 600-1000mcgs daily to maximize benefits. Not just that amount, but the best FORM of it is methylcobalamin. Most supplements use the cyanocoblamin form as it is cheaper, however, this form must then be converted by the body into methylcobalamin and is not always 100% efficient in doing so. Biotin is good for the skin and the hair, try for at least the DV, 300mcgs. FYI many people supplement with 10x that amount.

B-vitamins are water-soluble, meaning unused amounts are excreted in the urine. Therefore, it is important to space out intake throughout the day to ensure a constant blood level (as with all water-soluble vitamins).

Benfotiamine, a synthetic, fat-soluble form of Vitamin B1, has been shown to protect healthy cells in the presence of blood glucose, ie, prevents the onset of diabetes and protects cells from AGE's.