Wikipedia:
sodium-chloride symporter
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solute carrier family 12 (sodium/chloride transporters), member 3
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| Identifiers | |
| Symbol | SLC12A3 |
| Entrez | 6559 |
| HUGO | 10912 |
| OMIM | 600968 |
| RefSeq | NM_000339 |
| UniProt | P55017 |
| Other data | |
| Locus | Chr. 16 q13 |
The sodium-chloride symporter is a symporter ion pump used primarily to remove sodium and chloride ions from the distal convoluted tubule of the kidney.
Pathology
A deficiency in SLC12A3 is associated with Gitelman syndrome.
See also
External links
| Membrane transport protein: ion pumps | |
|---|---|
| Symporter, Cotransporter | Na+/K+/2Cl- - Na/Pi3 - Na+/Cl- - Na/glucose - Na+/I- |
| Antiporter (exchanger) | Na+/H+ - Na+/Ca2+ (Na+/(Ca2+-K+)) - Cl-/HCO3- (Band 3) |
| ATPase | Cu++ - Ca+ (SERCA-ATP2A2, [[Plasma membrane Ca2+ ATPase|Plasma membrane]]) - [[Na+/K+-ATPase|Na+/K+]] - H+/K+ - ATP synthase - H+ (F-type) - H+ (V-type) |
| Other | Uniporter - Halorhodopsin - Proton pump |
| Membrane proteins, carrier proteins: membrane transport proteins | |
|---|---|
| ABC-transporter | A12, B1, B2-3, B4, B5, B11, C4, C6, C8-9, D1, E1 |
| Solute carrier | 1A1-7, 1A3, 2A1, 2A2, 2A3, 2A4, 3A1, 3A2, 4A1, 5A1-2, 5A5, 6A2, 6A3, 6A4, 7A5, 7A9, 8A1-3, 9A3, 11A2, 12A1-2, 12A3, 17A6-8, 18A1, 18A2, 18A3, 19A2, 19A3, 22A5, 24A1-2, 24A5, 25A4-6, 25A13, 25A15, 25A20, 26A2, 26A4, 34A1, 39A4, 40A1 |
| Monosaccharide | GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT8 |
| Other | Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Karyopherin) |
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