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influenza pandemic of 1918–19
Most severe influenza outbreak of the 20th century. It apparently started as a fairly mild strain in a U.S. army camp in early March 1918. Troops sent to fight in World War I spread the virus to western Europe. Outbreaks occurred in nearly every inhabited part of the world, spreading from ports to cities along transportation routes. Pneumonia often developed quickly and killed within two days. Among the most deadly pandemics in history, it left an estimated 25 million dead; unusually, half the deaths were among 20- to 40-year-olds. The outbreak was later found to have been caused by an influenza virus known as influenza type A subtype H1N1.

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