n.
A crystalline polyamine compound, C10H26N4, present in ribosomes and found widely in living tissues along with spermidine. It was originally isolated from semen.
spermine
Dictionary:
sper·mine (spûr'mēn')  |
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| Veterinary Dictionary: spermine |
A polyamine first found in human semen but now known to occur in almost all tissues, in association with nucleic acids.
| Wikipedia: Spermine |
| Spermine | |
|---|---|
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| IUPAC name |
N,N'-bis(3-aminopropyl)butane-1,4-diamine
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| Other names | Gerontine Musculamine Neuridine |
| Identifiers | |
| CAS number | 71-44-3  |
| PubChem | 1103 |
| MeSH | Spermine |
| SMILES |
C(CCNCCCN)CNCCCN
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| Properties | |
| Molecular formula | C10H26N4 |
| Molar mass | 202.34 g/mol |
| Density | 0.937 g/cm3 |
| Melting point |
29 °C |
| Boiling point |
130 °C |
| (what is this?) (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine, it is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at physiological pH. Spermine is associated with nucleic acids and is thought to stabilize helical structure, particularly in viruses.
Crystals of spermine phosphate were first described in 1678, in human semen, by Anton van Leeuwenhoek[1]. The name spermin was first used by the German chemists Ladenburg and Abel in 1888[2], and the correct structure of spermine was not finally established until 1926, simultaneously in England (by Dudley, Rosenheim, and Starling)[3] and Germany (by Wrede. et al.)[4].
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See also
References
Notes
- ^ Leeuwenhoek, A. van (1678) Observationes D. Anthonii Leeuwenhoek, de natis e semine genitali animalculis. Letter dated November 1677. Philos. Trans. Roy. Soc. London, 12,1040-1043.
- ^ Ladenburg A., Abel J. (1888) Über das Aethylenimin (Spermin?). Ber. Dtsch. chem. Ges. 21: 758-766
- ^ Dudley H. W., Rosenheim O., Starling W. W. (1926) The chemical constitution of spermine. III.Structure and synthesis. Biochemical Journal 20(5): 1082-1094
- ^ Wrede F. (1925) Über die aus menschlichem Sperma isolierte Base Spermin. Dtsch. Med. Wochenschr. 51: 24
General references
- Slocum, R. D., Flores, H. E., "Biochemistry and Physiology of Polyamines in Plants", CRC Press, 1991, USA, ISBN 0-8493-6865-0
- Uriel Bachrach, "The Physiology of Polyamines", CRC Press, 1989, USA, ISBN 0-8493-6808-1
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 | spermi– (prefix) |
| polyamine |
| Spermine synthase |
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 | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Spermine". Read more |
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