"Stiff Man Syndrome" now usually called "Stiff Person Syndrome" is a rare disease of the nervous system that causes progressively severe muscle stiffness in the spine and legs. It is thought to be caused by an autoimmune disorder, where the enzyme responsible for making certain neurotransmitters is destroyed by the immune system.

Stiff person syndrome is very rare, so it is difficult to determine the exact prevalence of the disease. However, estimates are about 1 in 1 million people will get this disease. It is more common in diabetics, about 1 in 10 thousand people with diabetes will be affected.

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The cause of stiff person syndrome is unknown, however, researchers theorize that SPS may be an autoimmune disorder.

Stiff person syndrome (SPS) is an extremely rare progressive neurological disorder characterized by persistent rigidity and spasms of certain voluntary muscles, especially those of legs and feet.

Sjogren-Larsson syndrome is an inherited condition resulting in thickened, dry, rough skin (ichthyosis), mental retardation , and stiff, rigid muscles (spasticity ).