A highly contagious disease of the upper respiratory tract of horses and other members of the family Equidae, characterized by inflammation of the pharynx and abscess formation in lymph nodes. This disease occurs in horses of all ages throughout the world. The causative agent is Streptococcus equi, a clonal pathogen apparently derived from an ancestral strain of S. zooepidemicus. It is an obligate parasite of horses, donkeys, and mules. See also Streptococcus.
Strangles is most common and most severe in young horses, and is very prevalent on breeding farms. The causative agent has been reported to survive for 7 weeks in pus but dies in a week or two on pasture. Transmission is either direct by nose or mouth contact or aerosol, or indirect by flies, drinking buckets, pasture, and feed. The disease is highly contagious under conditions of crowding, exposure to severe climatic conditions such as rain and cold, and prolonged transportation. Carrier animals, although of rare occurrence, are critical in maintenance of the streptococcus and in initiation of outbreaks.
The mean incubation period is about 10 days, with a range of 3–14 days. The animal becomes quieter, has fever of 39–40.5°C (102–105°F), nasal discharge, loss of appetite, and swelling of one or more lymph nodes of the mouth. Pressure of a lymph node on the airway may cause respiratory difficulty. Abscesses in affected lymph nodes rupture in 7–14 days, and rapid clinical improvement and recovery then ensues. Recovery is associated with formation of protective antibodies in the nasopharynx and in the serum. See also Antibody.
Streptococcus equi is easily demonstrated in smears of pus from abscesses and in culture of pus or nasal swabs on colistin–nalidixic acid blood agar. Acutely affected animals also show elevated white blood cell counts and elevated fibrinogen.
Commercially available vaccines are injected in a schedule of two or three primary inoculations followed by annual boosters. However, the clinical attack rate may be reduced by only 50%, a level of protection much lower than that following the naturally occurring disease. See also Immunity.
Procaine penicillin G is the antibiotic of choice and quickly brings about reduction of fever and lymph node enlargement. See also Biologicals.