n., pl. -la (-lə).
An underlying supporting structure.
Subiculum
| Medical Dictionary: su·bic·u·lum |
n., pl. -la (-lə).
| 5min Related Video: Subiculum |
| Veterinary Dictionary: subiculum |
| Wikipedia: Subiculum |
| Brain: Subiculum | ||
|---|---|---|
.jpg) |
||
| Subiculum labeled at center left. | ||
 |
||
| Subiculum to CA1 transition Artist Don Cooper and Leah Leverich | ||
| Part of | Temporal lobe | |
| Artery | Posterior cerebral Anterior choroidal |
|
| Acronym(s) | S | |
| NeuroNames | hier-170 | |
| MeSH | Subiculum | |
| NeuroLex ID | birnlex_1305 | |
The subiculum (Latin for "support") is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.
It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, lateral hypothalamus, nucleus reuniens, mammillary nuclei, entorhinal cortex and amygdala.
The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking. The transitions between these two modes is thought to be important for routing information out of the hippocampus.
It is the site responsible for ictal activity in some cases of human epilepsy. It has also been implicated in working memory and drug addiction.
References
- Amaral, D.G., Witter, M.P. (1995). Hippocampal Formation. In: The Rat Nervous System. Academic Press, 1995.
- O'Mara, S.M., Commins, S., Anderson, M. & Gigg, J.(2001). The Subiculum: A review of form physiology and function. Prog Neurobiol, 64, 129-154.
- O’Mara, S.M. (2006). The Mammalian Subiculum: Contrasting and Complementary In Vivo and In Vitro Approaches to Subicular Function. Special Issue of Behavioural Brain Research, 174 (2), 197-312.
- "Switching Signals in the Brain," PLoS Biology, 3(6):e210, 2005 June.
- Donald C. Cooper, Sungkwon Chung, Nelson Spruston, "Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum," PLoS Biology, 3(6):e175, 2005 June.
- Donald C. Cooper, Shannon J. Moore, Nathan P. Staff, and Nelson Spruston, "Psychostimulant-induced plasticity of intrinsic excitability in the ventral subiculum," Journal of Neuroscience, October 29, 2003, 23(30):9937-9946
External links
 |
This neuroanatomy article is a stub. You can help Wikipedia by expanding it. |
|
|||||||||||||
|
||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Learn More
 | Brain anatomy |
| Perforant path |
| Alveus of the hippocampus |
Post a question - any question - to the WikiAnswers community:
Copyrights:
 |
 | Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
 |
| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
 |
| Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Subiculum". Read more |
|
