n., pl. -la (-lə).
An underlying supporting structure.
Subiculum
| Medical Dictionary: su·bic·u·lum |
(sə-bĭk'yə-ləm, sū-)
n., pl. -la (-lə).
n., pl. -la (-lə).
| 5min Related Video: Subiculum |
| Veterinary Dictionary: subiculum |
An underlying or supporting structure.
| Wikipedia: Subiculum |
| Brain: Subiculum | ||
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| Subiculum labeled at center left. | ||
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| Basic circuit of the hippocampus | ||
| Part of | Temporal lobe | |
| Artery | Posterior cerebral Anterior choroidal |
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| Acronym(s) | S | |
| NeuroNames | hier-170 | |
| MeSH | Subiculum | |
| NeuroLex ID | birnlex_1305 | |
The subiculum (Latin for "support") is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.
Contents |
Paths
It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, lateral hypothalamus, nucleus reuniens, mammillary nuclei, entorhinal cortex and amygdala.
The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking.[1] The transitions between these two modes is thought to be important for routing information out of the hippocampus.
Function
It is believed to play a role in some cases of human epilepsy.[2][3]
It has also been implicated in working memory[4] and drug addiction.[5]
It has been suggested that the dorsal subiculum is involved in spatial relations, and the ventral subiculum regulates the hypothalamic-pituitary-adrenal axis.[6]
References
- ^ Donald C. Cooper, Sungkwon Chung, Nelson Spruston, "Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum," PLoS Biology, 3(6):e175, 2005 June.
- ^ Knopp A, Frahm C, Fidzinski P, Witte OW, Behr J (June 2008). "Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy". Brain 131 (Pt 6): 1516–27. doi:. PMID 18504292. http://brain.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18504292.
- ^ Stafstrom CE (2005). "The role of the subiculum in epilepsy and epileptogenesis". Epilepsy Curr 5 (4): 121–9. doi:. PMID 16151518.
- ^ Riegert C, Galani R, Heilig S, Lazarus C, Cosquer B, Cassel JC (June 2004). "Electrolytic lesions of the ventral subiculum weakly alter spatial memory but potentiate amphetamine-induced locomotion". Behav. Brain Res. 152 (1): 23–34. doi:. PMID 15135966. http://linkinghub.elsevier.com/retrieve/pii/S0166432803003322.
- ^ Martin-Fardon R, Ciccocioppo R, Aujla H, Weiss F (July 2008). "The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking". Neuropsychopharmacology 33 (8): 1827–34. doi:. PMID 17957218. http://dx.doi.org/10.1038/sj.npp.1301589.
- ^ O'Mara S (September 2005). "The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us". J. Anat. 207 (3): 271–82. doi:. PMID 16185252. PMC 1571536. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0021-8782&date=2005&volume=207&issue=3&spage=271.
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 | Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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