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Sulfacetamide

 
Drug Info: Sulfacetamide

Brand names: AK-Sulf®Bleph-10®Carmol® Scalp TreatmentCetamide®Klaron®Mexar™Ocu-Sul®Ocusulf-10®Ovace®RE-10 WashRosula™ NSSeb-Prev™Sodium Sulamyd®Sulf-10®Sulf-15®

Chemical formula:



Sulfacetamide Sodium Ophthalmic ointment

What is this medicine?

SULFACETAMIDE (sul fa SEE ta mide) is a sulfonamide antibiotic. It is used to treat eye infections.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•eye injury or eye surgery
•an unusual or allergic reaction to sulfacetamide, sulfa drugs, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the tube to your eye, fingertips, or any other surface. Squeeze the end of the tube to apply a thin layer of the ointment to the inside of the lower eyelid. Close the eye gently to spread the ointment. Your vision may blur for a few minutes. Use your doses at regular intervals. Do not use your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional even if you think your condition is better.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

•eye products that contain silver

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not get better in 2 to 3 days. A full course of treatment is usually 7 to 10 days.

If you get any sign of an allergic reaction, stop using your eye product and call your doctor or health care professional.

Wear sunglasses if this medicine makes your eyes more sensitive to light. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•blurred vision that does not go away
•burning, blistering, peeling, stinging, or itching of the eyes or eyelids, skin or mouth
•eye redness, swelling, or pain

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•blurred vision for a few moments after application

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 2 and 30 degrees C (36 and 86 degrees F). Do not freeze. Throw away any unused eye products after the expiration date.

Last updated: 11/3/2003 2:57:00 PM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: sulfacetamide
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An antibacterial sulfonamide used mainly in ophthalmic preparations.

Wikipedia: Sulfacetamide
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Sulfacetamide
Systematic (IUPAC) name
N-[(4-aminophenyl)sulfonyl]acetamide
Identifiers
CAS number 144-80-9
ATC code S01AB04
PubChem 5320
DrugBank APRD00452
Chemical data
Formula C8H10N2O3S 
Mol. mass 214.243 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 7 to 12.8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Sulfacetamide is a sulfonamide antibiotic.

Contents

Uses

Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis.[1]

When combined with sulfur, it is sold under the brand name PLEXION and AVAR which is a 10% Sodium Sulfacetamide 5% Sulfur product.

Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor[2] and rosacea.[3] It may also have anti-inflammatory properties when used to treat blepharitis or even Conjunctivitis.[citation needed] It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa.[citation needed] Sodium Sulfacetamide has antibacterial activity and is used to control acne. Products containing sodium sulfacetamide (an antibacterial) and sulfur (a keratolytic) are commonly promoted for the treatment of acne rosacea (rosacea with papules, pustules, or both).

Adverse Effects

The most common adverse side effects of sodium sulfacetamide/sulfur combination products are local irritation and contact dermatitis. Sodium Sulfacetamide should not be used by individuals who have a sensitivity to sulfur of sulfa.

Applications

There are several prescription topical applications of Sodium Sulfacetamide. The line of OVACE products include a foam, shampoo, cream and wash. Ovace is sulfur free and fragrance free so there is no unpleasant odor after application and it is non-irritating. It also does not contain sodium metabisulfite which is associated with allergic-type reactions in certain susceptible individuals.

Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism.[4]

Glossary

Seborrheic Dermatitis A common, chronic, inflammatory, erythematous (red) scaling eruption that occurs in areas where there are a large number of sebaceous glands, scalp, sides of nose, hairline, eyebrows, eyelids, behind the ears and mid chest. Other areas include the navel, groin, armpits, breasts and buttocks.


Keratolytic An agent that aids the breakdown and removal of old skin cells.

Papules Solid elevations of the skin; bumps.

References

  1. ^ http://www.drugs.com/mtm/klaron.html
  2. ^ Hull CA, Johnson SM (June 2004). "A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor". Cutis 73 (6): 425–9. PMID 15224788. 
  3. ^ Del Rosso JQ (January 2004). "Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations". Cutis 73 (1 Suppl): 29–33. PMID 14959943. 
  4. ^ Mastrolorenzo A, Supuran CT (2000). "Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives". Met Based Drugs 7 (1): 49–54. doi:10.1155/MBD.2000.49. PMID 18475922. 




 
 

 

Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Sulfacetamide" Read more