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Teriparatide

 
Drug Info: Teriparatide

Brand names: Forteo™

Chemical formula:



Teriparatide Solution for injection

What is this medicine?

TERIPARATIDE (terr ih PAR a tyd) increases bone mass and strength. It helps make healthy bone and to slow bone loss. This medicine is used to prevent bone fractures.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•bone disease other than osteoporosis
•heart, kidney or liver disease
•history of cancer in the bone
•kidney stone
•Paget's disease
•parathyroid disease
•receiving radiation therapy
•an unusual or allergic reaction to teriparatide, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine comes in an injection pen device. This pen injects the medicine under your skin. Follow the directions on the prescription label. You will be taught how to use this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Do not use this medicine if it has solid particles in it, or if it is cloudy or colored. It should be clear and colorless.

Be sure that you are using your pen device correctly. A patient information sheet for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

•digoxin
•other medicines to strengthen bone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Your doctor may order blood tests and other tests to see how you are doing.

You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Discuss the foods you eat and the vitamins you take with your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•chronic constipation
•high blood pressure
•irregular heartbeat, chest pain
•nausea, vomiting
•unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•bone pain
•cough, runny nose
•headache
•leg cramps
•muscle spasms in the back or legs
•pain, redness, irritation or swelling at the injection site
•stomach upset
•trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze. Recap the pen injector when not in use to protect it from light and damage. Use quickly after taking out of the refrigerator and return to refrigerator right after using. Throw away any unused medicine 28 days after the first injection from the device. Do not use after the expiration date printed on the pen and pen packaging.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Wikipedia: Teriparatide
Top
Teriparatide
Systematic (IUPAC) name
 ?
Identifiers
CAS number 52232-67-4
ATC code H05AA02
PubChem 16133850
Chemical data
Formula C181H291N55O51S2 
Mol. mass 4117.72 g/mol
Pharmacokinetic data
Bioavailability 95%
Metabolism Hepatic (nonspecific proteolysis)
Half life SubQ: 1 hour
Excretion Renal (metabolites)
Therapeutic considerations
Pregnancy cat.

C

Legal status
Routes SubQ

Teriparatide (Forteo) is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis.[1] It is manufactured and marketed by Eli Lilly and Company.

Contents

Administration

Teriparatide is administered by injection once a day in the thigh or abdomen. The recommended dose is 20 μg per day.

Uses

Teriparatide has an ongoing clinical trial to evaluate its effectiveness in treating the symptoms of osteogenesis imperfecta.[2]

Teriparatide should not be prescribed for patients who are at increased risks for osteosarcoma. This includes those with Paget's Disease of bone or unexplained elevations of serum alkaline phosphate, open epiphysis, or prior radiation therapy involving the skeleton.

Side Effects

The main risk of teriparatide is an increased risk of osteosarcoma.[citation needed] Because of this risk, it is typically used as second line therapy and even then for no more than two years.[citation needed]

Mechanism of action

Teriparatide is the portion of human parathyroid hormone (PTH), amino acid sequence 1 through 34, of the complete molecule (containing 84 amino acids). Endogenous PTH is the primary regulator of calcium and phosphate metabolism in bone and kidney. PTH increases serum calcium, partially accomplishing this by increasing bone resorption. Thus, chronically elevated PTH will deplete bone stores. However, intermittent exposure to PTH will activate osteoblasts more than osteoclasts. Thus, once-daily injections of teriparatide have a net effect of stimulating new bone formation leading to increased bone mineral density.

Teriparatide is the first FDA approved agent for the treatment of osteoporosis that stimulates new bone formation.

FDA approval

Teriparatide was approved by the Food and Drug Administration (FDA) on 26 November 2002, for the treatment of osteoporosis in men and postmenopausal women who are at high risk for having a fracture. The drug is also approved to increase bone mass in men with primary or hypogonadal osteoporosis who are at high risk for fracture.

References

One randomized trial of postmenopausal women who had already fractured vertebra compared teriparatide at either 20 or 40 micrograms per day with placebo. After about 19 months, 14% of the women taking placebo had new vertebral fractures, as compared with 5% of the women taking 20 micrograms of teriparatide and 4% of the women taking 40 micrograms. There were also a statistically significant lower number of non-vertebral fractures in the teriparatide treated group. 20 micrograms of teriparatide increased spine and hip bone mineral density. no

N Engl J Med. 2001 May 10;344(19):1434-41.

External links


 
 
Learn More
Teriparatide Solution for injection
osteoporosis (disease)
Zoledronic Acid injection (Paget's disease, Osteoporosis, Reclast)

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