n.
A white compound, C10H7N3S, used medically as an antifungal agent and as an anthelmintic.
[THIA(ZOLE) + BEN(ZO)- + (IMI)D(E) + AZOLE.]
thiabendazole
Dictionary:
thi·a·ben·da·zole (thī'ə-bĕn'də-zōl') 
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n.
A white compound, C10H7N3S, used medically as an antifungal agent and as an anthelmintic.
| 5min Related Video: thiabendazole |
| Dental Dictionary: thiabendazole |
(thī′-əben′dəzōl)
n
n
Anthelmintic agent most effective against infection with the roundworm Strongyloides. Its effectiveness in treating other roundworm infections is varied.
| Drug Info: Thiabendazole |
Brand names: Mintezol®
Chemical formula:
- Drug Forms:
- Thiabendazole Chewable tablet (below)
- Thiabendazole Oral suspension
Thiabendazole Chewable tablet
What is this medicine?
THIABENDAZOLE is an anthelmintic. It is used to treat infections caused by roundworms, hookworms, pinworms, whipworms, or threadworms.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•anemia
•dehydration
•kidney disease
•liver disease
•malnutrition
•other chronic illness
•an unusual or allergic reaction to thiabendazole, other medicines, foods, dyes or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
Take this medicine by mouth. Follow the directions on the prescription label. Chew or crush the tablets before swallowing. Take after meals. You can mix this medicine with juice or semi-solid food (such as applesauce or pudding). Take at regular intervals. Do not take your medicine more often than directed. Finish the full course of medicine prescribed by your doctor or health care professional even if you feel better.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose, Do not take double or extra doses.What may interact with this medicine?
•aminophylline
•caffeine
•theophylline
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional to check that your infection has gone. If you have a severe infection you may need a second course of tablets.
Wash your hands, scrub your fingernails and shower often. Every day change and launder bedclothes, linens, and undergarments. This will help keep other family members from getting infected. Disinfect the toilet every day, and damp mop the floors often to reduce the number of worm eggs.
Other people in your house may need treatment. Check with your doctor or health care professional as some worms are spread easily. Treat cats and dogs regularly for worms.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•blurred vision
•diarrhea
•difficulty breathing
•dry eyes
•dry mouth or persistent cough
•fever or chills, sore throat
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•seizures
•unusually weak or tired
•yellowing of eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•dizziness
•loss of appetite
•nausea, vomiting
•ringing in the ears
•stomach pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Veterinary Dictionary: thiabendazole |
A very safe and effective, broad-spectrum anthelmintic used widely in sheep. Also used extensively in horses in combination with piperazine. Poisoning with thiabendazole has been recorded but it is a very unusual occurrence requiring a massive overdose. It is capable of causing incoordination and collapse initially, and subsequently toxic nephrosis with terminal uremia.
| Wikipedia: Tiabendazole |
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Tiabendazole
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| Systematic (IUPAC) name | |
| 4-(1H-1,3-benzodiazol-2-yl)-1,3-thiazole | |
| Identifiers | |
| CAS number | |
| ATC code | D01 P02 QP52 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C10H7N3S |
| Mol. mass | 201.249 g/mol |
| SMILES | & |
| Physical data | |
| Density | 1.103 g/cm³ |
| Melt. point | 293–305 °C (559–581 °F) |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | GI tract. Peak plasma 1-2 hours through oral admin. |
| Half life | 8 hours |
| Excretion | 90% Urine
5% Faeces |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Tiabendazole (INN, other names include TBZ, thiabendazole and the trade names Mintezol, Tresaderm, and Arbotect) is a fungicide and parasiticide.
Contents |
Uses
Fungicide
It is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables; it is also used as a prophylactic treatment for Dutch Elm disease.
Use in treatment of Aspergillus has been reported.[1]
Parasiticide
As an antiparasitic, it is able to control roundworms (such as Strongyloidiasis)[2], hookworms, and other helminth species which attack wild animals, livestock and humans. [3]
Pharmacodynamics / Mode of Action
Inhibition of the mitochondrial helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone.[4]
Other
Medicinally, thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
In dogs and cats thiabendazole is also used to treat ear infections.
Thiabendazole is also used as a food additive[5][6], a preservative with E number E233. For example, it is applied to bananas to ensure freshness, and is a common ingredient in the waxes applied to the skin of citrus fruits.
Safety
The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestine disorder at high exposure in test animals (just below LD50 level).[citation needed] Some reproductive disorders and decreasing weanling weight have been observed, also at high exposure. Effects on humans from use as drug includes nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine.[citation needed] No mutagenic or carcinogenic effects have been shown.
See also
References
- ^ Upadhyay MP, West EP, Sharma AP (January 1980). "Keratitis due to Aspergillus flavus successfully treated with thiabendazole". Br J Ophthalmol 64 (1): 30–2. PMID 6766732. PMC: 1039343. http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=6766732.
- ^ Igual-Adell R, Oltra-Alcaraz C, Soler-Company E, Sánchez-Sánchez P, Matogo-Oyana J, Rodríguez-Calabuig D (December 2004). "Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis". Expert Opin Pharmacother 5 (12): 2615–9. doi:. PMID 15571478. http://www.informapharmascience.com/doi/abs/10.1517/14656566.5.12.2615.
- ^ Portugal R, Schaffel R, Almeida L, Spector N, Nucci M (June 2002). "Thiabendazole for the prophylaxis of strongyloidiasis in immunosuppressed patients with hematological diseases: a randomized double-blind placebo-controlled study". Haematologica 87 (6): 663–4. PMID 12031927. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=12031927.
- ^ Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 970
- ^ Rosenblum C (March 1977). "Non-drug-related residues in tracer studies". Journal of Toxicology and Environmental Health 2 (4): 803–14. PMID 853540.
- ^ Sax, N.I. Dangerous Properties of Industrial Materials. Vol 1-3 7th ed. New York, NY: Van Nostrand Reinhold, 1989., p. 3251
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