A hormone secreted by the hypothalamus that stimulates release of thyrotropin.
Dictionary:
thy·ro·tro·pin-re·leas·ing hormone (thī'rə-trō'pĭn-rĭ-lē'sĭng, thī-rŏt'rə-) ![]() |
A hormone secreted by the hypothalamus that stimulates release of thyrotropin.
| Medical Dictionary: thyrotropin-releasing hormone |
(Abbr. TRH) A tripeptide hormone secreted by the hypothalamus that stimulates the release of thyrotropin. Also called thyroliberin.
| WordNet: thyrotropin-releasing hormone |
The noun has one meaning:
Meaning #1:
hormone released by the hypothalamus that controls the release of thyroid-stimulating hormone from the anterior pituitary
Synonyms: TRH, thyrotropin-releasing factor, TRF, protirelin
| Wikipedia: Thyrotropin-releasing hormone |
| Structural formula of TRH | |
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thyrotropin-releasing hormone
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| Identifiers | |
| Symbol | TRH |
| Entrez | 7200 |
| HUGO | 12298 |
| OMIM | 275120 |
| RefSeq | NM_007117 |
| UniProt | P20396 |
| Other data | |
| Locus | Chr. 3 q13.3-q21 |
Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF), thyroliberin or protirelin, is a tropic tripeptide hormone that stimulates the release of thyroid-stimulating hormone and prolactin by the anterior pituitary.
Contents |
TRH is produced by the hypothalamus in medial neurons of the paraventricular nucleus.[1] Initially, it is synthesized as a 242 amino acid precursor polypeptide that contains 6 copies of the sequence -Glu-His-Pro-Gly-, flanked by di-basic peptides that are later processed through proteolysis to give the mature TRH molecule.
It travels across the median eminence to the anterior pituitary gland via the hypophyseal portal system where it stimulates the release of thyroid stimulating hormone from cells called thyrotropes.[2]
In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets.
The sequence of TRH was first determined and the hormone synthesized by Roger Guillemin and Andrew V. Schally in 1969.[3][4] Both parties insist their labs determined it first: Schally first suggested the possibility in 1966, but abandoned it after Guillemin proposed TRH was not actually a peptide. Guillemin's chemist began concurring with these results in 1969, as NIH threatened to cut off funding for the project, leading both parties to return to work on synthesis.[5]
Half of the 1977 Nobel Prize in Medicine was awarded to Schally and Guillemin "for their discoveries concerning the peptide hormone production of the brain."[6] News accounts of their work often focus on their "fierce competition" and use of tons of sheep and pig brains to locate the hormone.[5]
Its molecular weight is 359.5 Da.
Its tripeptide structure is: (pyro)Glu-His-Pro-NH2
It is used in pharmacology (brand name Relefact TRH) to test the response of the anterior pituitary gland.
Medical preparations of TRH are used in diagnostic tests of thyroid disorders and in acromegaly.
A TRH test may be indicated if secondary hypothyroidism is suspected.
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![]() | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved. Read more | |
![]() | Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more | |
![]() | WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. Read more | |
![]() | Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thyrotropin-releasing hormone". Read more |