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Ticarcillin

 

A broad-spectrum penicillin that is active against Pseudomonas and Proteus bacteria. It is used in combination with clavulanic acid for the treatment of systemic (generalized) and local infections (such as infected wounds or burns) and respiratory and urinary-tract infections. Given by infusion, it is available on prescription only. It is sometimes used in conjunction with an aminoglycoside antibiotic.

Side effects, precautions, and interactions with other drugs:
see benzylpenicillin.

Proprietary preparation:
Timentin (combined with clavulanic acid).

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American Heritage Stedman's Medical Dictionary:

ti·car·cil·lin disodium

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('kär-sĭl'ĭn)
n.

The disodium salt of a semisynthetic bactericide used in the treatment of Pseudomonas aeruginosa infections.

A semisynthetic penicillin with an extended spectrum of activity.

Wikipedia on Answers.com:

Ticarcillin

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Ticarcillin
Systematic (IUPAC) name
(2S,5R,6R)-6-{[(2S)-2-carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a685037
Pregnancy cat. B2(AU) B(US)
Legal status Prescription only
Routes Intravenous
Pharmacokinetic data
Protein binding 45%
Half-life 1.1 hours
Excretion Renal
Identifiers
CAS number 34787-01-4 YesY
ATC code J01CA13 J01CR03
PubChem CID 36921
DrugBank DB01607
ChemSpider 33876 YesY
UNII F93UJX4SWT YesY
KEGG D08593 YesY
ChEBI CHEBI:9587 YesY
ChEMBL CHEMBL1449 YesY
Chemical data
Formula C15H16N2O6S2 
Mol. mass 384.429 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Ticarcillin is a carboxypenicillin. It is almost invariably[citation needed] sold and used in combination with clavulanate as Timentin. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram-negative bacteria, in particular, Pseudomonas aeruginosa. It is also one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections.

It is provided as a white or pale-yellow powder. It is highly soluble in water, but should be dissolved only immediately before use to prevent degradation.

Contents

Mechanism of action

Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria tries to divide, causing cell death.

Ticarcillin, like penicillin, contains a β-lactam ring that can be cleaved by β-lactamases, resulting in inactivation of the antibiotic. Those bacteria that can express β-lactamases are, therefore, resistant to β-lactam antibiotics. Due, at least in part, to the common β-lactam ring, ticarcillin can cause reactions in patients allergic to penicillin. Ticarcillin is also often paired with a β-lactamase inhibitor such as clavulanic acid.

Other uses

In molecular biology, ticarcillin is used to as an alternative to ampicillin to test the uptake of marker genes into bacteria. It prevents the appearance of satellite colonies that occur when ampicillin breaks down in the media. It is also used in plant molecular biology to kill agrobacterium, which is used to deliver genes to plant cells.

Dosing and posology

Ticarcillin is not absorbed orally, and therefore must be given by intravenous or intramuscular injection

Trade names and preparations

  • Ticarcillin: Ticar (Formerly marketed by Beecham, then SmithKline Beecham until 1999, when it merged with Glaxo to form GlaxoSmithKline; it is no longer available in the UK. US distribution ceased in 2004. Ticar was replaced by Timentin.)



 
 
Related topics:
Ticarcillin
Ticarcillin; Clavulanic Acid
carboxypenicillin

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Copyrights:

 Oxford A-Z of Medicinal Drugs. Market University Press. © 2000, 2003, 2010 An A-Z of Medicinal Drugs. All rights reserved.  Read more
American Heritage Stedman's Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
Saunders Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia on Answers.com. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Ticarcillin Read more

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