tragic flaw

n.
A flaw in the character of the protagonist of a tragedy that brings the protagonist to ruin or sorrow.

tragic flaw, the defect of character that brings about the protagonist's downfall in a tragedy: Othello's jealousy is a famous example. The idea of the tragic flaw involves a narrowing and personalizing of the broader Greek concept of hamartia (‘error’ or ‘failure’). See also hubris.

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The noun has one meaning:

Meaning #1: the character flaw or error of a tragic hero that leads to his downfall
  Synonym: hamartia

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