In the traditional sense of 'tribulation' -

The loss of my home was a great tribulation to me and my family.

In the theological sense of 'tribulation' -

The 'Tribulation' is a theological invention of John Nelson Darby, the nineteenth-century founder of the Plymouth Brethren, but is now accepted as fact by millions of Christians.

House of Payne - 2006 Trial and Tribulation was released on:

USA: 3 August 2012

Great affliction, trial, or distress, suffering, An experience that tests one's endurance, patience, or faith.

disaster, calamity, cataclysm, holocaust, havoc, ruin, ruination, tragedy; adversity, blight, trouble, trial, tribulation.

The plural of tribulation is tribulations.

As in "these are some big tribulations".