Results for trimethadione
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Dictionary:

trimethadione

  (trī-mĕth'ə-dī'ōn') pronunciation
n.

A white crystalline substance, C6H9NO3, used as an anticonvulsant in the treatment of epilepsy.

[TRI– + METH(YL) + DI–1 + –ONE.]


 
 
Dental Dictionary: trimethadione

n

trade name: Tridione; drug class: anticonvulsant; action: increases the threshold for seizures initiated in the cortex, decreases central nervous system (CNS) synaptic stimulation to low-frequency impulses; use: treatment of refractory absence (petit mal) seizures.

 
Medical Dictionary: tri·meth·a·di·one
(trī-mĕth'ə-dī'ōn')
n.

A white crystalline substance used as an anticonvulsant in the treatment of epilepsy.

 
Wikipedia: trimethadione
Trimethadione.svg
Trimethadione
Systematic (IUPAC) name
3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
Identifiers
CAS number 127-48-0
ATC code N03AC02
PubChem 5576
DrugBank APRD00315
Chemical data
Formula C6H9NO3 
Mol. mass 143.141
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

X

Legal status

Prescription only

Routes  ?

Trimethadione is an oxazolidinedione anticonvulsant. It is used to treat epileptic conditions that are resistant to other treatments; recent studies by Doctor Jianxin Bao, Ph.D., at Washington University in Saint Louis's Central Institute For The Deaf's Center For Presbyacusis and Aging suggest that trimethadione, along with other oxazolidinedione anticonvulsant medications may be useful in treating sensorineural hearing loss cases like those of Iraq war veterans- if the drug's side effects, like dizziness, can be lessened by modifying the drug so it does not cross into the brain itself.

If administered during pregnancy, fetal trimethadione syndrome may result causing Facial Dysmorphism(short upturned nose,slanted eyebrows), cardiac defects,Intra Uterine Growth Retardation,mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]

References

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Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved.  Read more
Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Trimethadione" Read more

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