Using the Group Policy Editor
· Click Start, Run and type gpedit.msc and press ENTER
· Go to the following location:
User Configuration Administrative Templates System
· Double-click Disable registry editing tools and set it to
Disable
· Minimize the Group Policy Editor for now, and try to launch
the Tweak UI, you should be able to launch it now
· Go back to the Group Policy Editor, and set the "Disable
registry editing tools" back to Not Configured
Source:
http://geekvalley.blogspot.com/2008/06/tweak-ui-has-been-disabled-by-your.html