uneasiness

1. The quality or state of being uneasy; restlessness; disquietude; anxiety.

2. The quality of making uneasy; discomfort; as, the uneasiness of the road. [Obs.] Bp. Burnet.

noun

1. A troubled or anxious state of mind: angst, anxiety, anxiousness, care, concern, disquiet, disquietude, distress, nervousness, solicitude, unease, worry. See feelings.
2. An uneasy or nervous state: disquiet, disquietude, inquietude, restiveness, restlessness, unease, unrest. See calm/agitation.

The noun has 5 meanings:

Meaning #1: feelings of anxiety that make you tense and irritable
  Synonyms: edginess, inquietude, disquietude

Meaning #2: physical discomfort (as mild sickness or depression)
  Synonyms: malaise, unease

Meaning #3: embarrassment deriving from the feeling that others are critically aware of you
  Synonyms: self-consciousness, uncomfortableness

Meaning #4: the trait of seeming ill at ease
  Synonyms: disquiet, unease

Meaning #5: inability to rest or relax or be still
  Synonym: restlessness