Too much alcohol

Guanidine compounds, such as guanidinosuccinic acid, are used to determine the diagnosis or buildup of urea in uremic patients.

Because the buildup of urea in uremic plasma results in an inhibitory effect on enzymes in the urea cycle, it can cause the activation of alternte metabolic pathways that lead to the buildup of compounds such as guanidinosuccinic acid.

It is called uremic frost. End stage of renal failure.

kidney failure which may b acute or chronic

Shigellosis can cause hemolytic uremic syndrome or HUS which leads to kidney failure.