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vitamin B complex

 
American Heritage Dictionary:

vitamin B complex


n.
A group of water-soluble vitamins including thiamine, riboflavin, niacin, pantothenic acid, biotin, pyridoxine, folic acid, inositol, and vitamin B12 and occurring chiefly in yeast, liver, eggs, and some vegetables. Also called B complex.


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Oxford Dictionary of Chemistry:

vitamin B complex

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A group of water-soluble vitamins that characteristically serve as components of coenzymes. Plants and many microorganisms can manufacture B vitamins but dietary sources are essential for most animals. Heat and light tend to destroy B vitamins.

Vitamin B1 (thiamin(e)) is a precursor of the coenzyme thiamine pyrophosphate, which functions in carbohydrate metabolism. Deficiency leads to beriberi in humans and to polyneuritis in birds. Good sources include brewer's yeast, wheatgerm, beans, peas, and green vegetables.

Vitamin B2 (riboflavin) occurs in green vegetables, yeast, liver, and milk. It is a constituent of the coenzymes FAD and FMN, which have an important role in the metabolism of all major nutrients as well as in the oxidative phosphorylation reactions of the electron transport chain. Deficiency of B2 causes inflammation of the tongue and lips and mouth sores.

Vitamin B6 (pyridoxine) is widely distributed in cereal grains, yeast, liver, milk, etc. It is a constituent of a coenzyme (pyridoxal phosphate) involved in amino acid metabolism. Deficiency causes retarded growth, dermatitis, convulsions, and other symptoms.

Vitamin B12 (cyanocobalamin; cobalamin) is manufactured only by microorganisms and natural sources are entirely of animal origin. Liver is especially rich in it. One form of B12 functions as a coenzyme in a number of reactions, including the oxidation of fatty acids and the synthesis of DNA. It also works in conjunction with folic acid (another B vitamin) in the synthesis of the amino acid methionine and it is required for normal production of red blood cells. Vitamin B12 can only be absorbed from the gut in the presence of a glycoprotein called intrinsic factor; lack of this factor or deficiency of B12 results in pernicious anaemia.

Other vitamins in the B complex include nicotinic acid, pantothenic acid, biotin, and lipoic acid. See also choline.




Vitamin B1



Vitamin B2



Vitamin B6



Britannica Concise Encyclopedia:

vitamin B complex

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Water-soluble organic compounds with loosely similar properties, distribution in natural sources, and physiological functions. Most are coenzymes, and all appear essential to the metabolic processes of all animal life. They include thiamin (B1), riboflavin (B2), niacin, vitamin B6, pantothenic acid, folic acid, biotin, and vitamin B12 (cobalamin); some authorities also include choline, carnitine, lipoic acid, inositol, and para-aminobenzoic acid. Vitamin B6 is needed for metabolism of amino acids and prevention of skin and nerve disorders. Vitamin B12 prevents pernicious anemia and is involved in nucleic-acid synthesis, fat metabolism, and conversion of carbohydrate to fat. The B complex vitamins are particularly abundant in cereal grains, meats, nuts, and some fruits and vegetables.

For more information on vitamin B complex, visit Britannica.com.

Oxford Food & Nutrition Dictionary:

vitamin B complex

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An old-fashioned term for the various B vitamins: vitamin B1 (thiamin), vitamin B2 (riboflavin), niacin, vitamin B6, vitamin B12, folate, biotin, and pantothenic acid. These vitamins occur together in cereal germ, liver, and yeast; function as coenzymes; and historically were discovered by separation from what was known originally as vitamin B; hence, they are grouped together as the B complex.

Oxford A-Z of Medicinal Drugs:

vitamin B complex

Top

A group of water-soluble vitamins that, although not chemically related, are often found together in the same kinds of food (including milk, liver, and cereals).

Vitamin B1 (see thiamine) is required for carbohydrate metabolism; a deficiency leads to beriberi. Vitamin B2 (see riboflavin) is important for oxygen exchange in the tissues. Vitamin B6 (see pyridoxine) is involved in protein metabolism. Vitamin B12 (see cyanocobalamin; hydroxocobalamin) is necessary for the synthesis of nucleic acids (DNA and RNA), the maintenance of myelin (an important component of certain nerve cells), and the proper functioning of folic acid. B12 can be absorbed only in the presence of intrinsic factor, a protein secreted in the stomach. A deficiency of vitamin B12 affects nearly all the body tissues, particularly those containing rapidly dividing cells. The most serious effects of a deficiency are pernicious anaemia (due to deficiency of intrinsic factor) and degeneration of the nervous system. Vitamin B12 is contained only in foods of animal origin. Other members of the B complex include nicotinamide, aminobenzoic acid, pantothenic acid, panthenol, inositol, and biotin.

B group vitamins are used to treat specific diseases due to deficiencies of these vitamins and also to prevent deficiency in people considered to be at risk (e.g. pregnant women). They are available as specific vitamin supplements and are also included in numerous multivitamin preparations; many iron supplements also contain B group vitamins.

Proprietary preparations:
Vigranon B; Abidec Multivitamin Drops (combined with vitamins A, C, and D); Dalivit (combined with vitamins A, C, and D); Pabrinex (combined with vitamin C); Vivioptal (combined with vitamin A, vitamin C, vitamin D, vitamin E, and various minerals and trace elements); Yeast-Vite (combined with caffeine).

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Wikipedia on Answers.com:

B vitamins

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B vitamins are a group of water-soluble vitamins that play important roles in cell metabolism. The B vitamins were once thought to be a single vitamin, referred to as vitamin B (much as people refer to vitamin C or vitamin D). Later research showed that they are chemically distinct vitamins that often coexist in the same foods. In general, supplements containing all eight are referred to as a vitamin B complex. Individual B vitamin supplements are referred to by the specific name of each vitamin (e.g., B1, B2, B3 etc.).

Contents

List of B vitamins

Health benefits

The B vitamins may be necessary to:

All B vitamins are water-soluble, and are dispersed throughout the body. Most of the B vitamins must be replenished regularly, since any excess is excreted in the urine.[4]

B vitamins have also been hypothesized to improve the symptoms of attention deficit hyperactivity disorder.[5]

B vitamin deficiency

Several named vitamin deficiency diseases may result from the lack of sufficient B-vitamins. Deficiencies of other B vitamins result in symptoms that are not part of a named deficiency disease.

Vitamin Name Deficiency effects
Vitamin B1 thiamine Deficiency causes beriberi. Symptoms of this disease of the nervous system include weight loss, emotional disturbances, Wernicke's encephalopathy (impaired sensory perception), weakness and pain in the limbs, periods of irregular heartbeat, and edema (swelling of bodily tissues). Heart failure and death may occur in advanced cases. Chronic thiamine deficiency can also cause Korsakoff's syndrome, an irreversible psychosis characterized by amnesia and confabulation.
Vitamin B2 riboflavin Deficiency causes ariboflavinosis. Symptoms may include cheilosis (cracks in the lips), high sensitivity to sunlight, angular cheilitis, glossitis (inflammation of the tongue), seborrheic dermatitis or pseudo-syphilis (particularly affecting the scrotum or labia majora and the mouth), pharyngitis (sore throat), hyperemia, and edema of the pharyngeal and oral mucosa.
Vitamin B3 niacin Deficiency, along with a deficiency of tryptophan causes pellagra. Symptoms include aggression, dermatitis, insomnia, weakness, mental confusion, and diarrhea. In advanced cases, pellagra may lead to dementia and death (the 3(+1) Ds: dermatitis, diarrhea, dementia, and death).
Vitamin B5 pantothenic acid Deficiency can result in acne and paresthesia, although it is uncommon.
Vitamin B6 pyridoxine Deficiency may lead to microcytic anemia (because pyridoxyl phosphate is the cofactor for heme synthesis), depression, dermatitis, high blood pressure (hypertension), water retention, and elevated levels of homocysteine.
Vitamin B7 biotin Deficiency does not typically cause symptoms in adults but may lead to impaired growth and neurological disorders in infants. Multiple carboxylase deficiency, an inborn error of metabolism, can lead to biotin deficiency even when dietary biotin intake is normal.
Vitamin B9 folic acid Deficiency results in a macrocytic anemia, and elevated levels of homocysteine. Deficiency in pregnant women can lead to birth defects. Supplementation is often recommended during pregnancy. Researchers have shown that folic acid might also slow the insidious effects of age on the brain.
Vitamin B12 cobalamin Deficiency results in a macrocytic anemia, elevated homocysteine, peripheral neuropathy, memory loss and other cognitive deficits. It is most likely to occur among elderly people, as absorption through the gut declines with age; the autoimmune disease pernicious anemia is another common cause. It can also cause symptoms of mania and psychosis. In rare extreme cases, paralysis can result.

B vitamin toxicity

Although most B vitamins are eliminated regularly in the urine, taking large doses of certain B vitamins may produce harmful effects.

Vitamin Name Tolerable Upper Intake Level Harmful effects
Vitamin B1 thiamine None[6] No known toxicity from oral intake. There are some reports of anaphylaxis caused by high-dose thiamin injections into the vein or muscle. However, the doses were greater than the quantity humans can physically absorb from oral intake.[6]
Vitamin B2 riboflavin None.[7] No evidence of toxicity based on limited human and animal studies. The only evidence of adverse effects associated with riboflavin comes from in vitro studies showing the production of reactive oxygen species (free radicals) when riboflavin was exposed to intense visible and UV light.[7]
Vitamin B3 niacin 35 mg/day from supplements, drugs or fortified food[8] Intake of 3000 mg/day of nicotinamide and 1500 mg/day of nicotinic acid are associated with nausea, vomiting, and signs and symptoms of liver toxicity. Other effects may include glucose intolerance, and (reversible) ocular effects. Additionally, the nicotinic acid form may cause vasodilatory effects, also known as flushing, including redness of the skin, often accompanied by an itching, tingling, or mild burning sensation, which is also often accompanied by pruritus, headaches, and increased intracranial blood flow, and occasionally accompanied by pain.[8] Medical practitioners prescribe recommended doses up to 2000 mg. per day of niacin, usually in time release format, to combat arterial plaque development in cases of high lipid levels.[9]
Vitamin B5 pantothenic acid None No known toxicity
Vitamin B6 pyridoxine 100 mg/day from supplements, drugs or fortified food[10] Intake of more than 1000 mg/day is associated with peripheral sensory neuropathy; other effects are unconfirmed: dermatological lesions [causal association is unlikely]; B6 dependency in newborns [causal association is also unlikely].[10]
Vitamin B7 biotin None No known toxicity
Vitamin B9 folic acid 1 mg/day [11] Masks B12 deficiency, which can lead to permanent neurological damage[11]
Vitamin B12 cobalamin None established.[12] Acne-like rash [causality is not conclusively established].[12][13]

B vitamin sources

B vitamins are found in whole unprocessed foods. Processed carbohydrates such as sugar and white flour tend to have lower B vitamin than their unprocessed counterparts. B vitamins are particularly concentrated in meat such as turkey and tuna, in liver and meat products.[14] Good sources for B vitamins include kombucha, whole grains, potatoes, bananas, lentils, chili peppers, tempeh, beans, nutritional yeast, brewer's yeast, and molasses. Although the yeast used to make beer results in beers being a source of B vitamins,[15] their bioavailability ranges from poor to negative as drinking ethanol inhibits absorption of thiamine (B1),[16][17] riboflavin (B2),[18] niacin (B3),[19] biotin (B7),[20] and folic acid (B9).[21][22] In addition, each of the preceding studies further emphasizes that elevated consumption of beer and other ethanol-based drinks results in a net deficit of those B vitamins and the health risks associated with such deficiencies.

The B12 vitamin is of note because it is not available from plant products, making B12 deficiency a concern for vegans. Manufacturers of plant-based foods will sometimes report B12 content, leading to confusion about what sources yield B12. The confusion arises because the standard US Pharmacopeia (USP) method for measuring the B12 content does not measure the B12 directly. Instead, it measures a bacterial response to the food. Chemical variants of the B12 vitamin found in plant sources are active for bacteria, but cannot be used by the human body. This same phenomenon can cause significant over-reporting of B12 content in other types of foods as well.[23]

Vitamin B may also be delivered by injection to reverse deficiencies.[24]

Another popular means of increasing one's vitamin B intake is through the use of dietary supplements. B vitamins are also commonly added to energy drinks, many of which have been marketed with large amounts of B vitamins[25] with claims that this will cause the consumer to "sail through your day without feeling jittery or tense."[25] Nutritionists, such as Case Western University Professor Hope Barkoukis, dismiss these claims: "It's brilliant marketing, but it doesn't have any basis [in fact]."[25]

While B vitamins do "help unlock the energy in foods," just about everyone in America already gets all of the B vitamins they could possibly need in their diets.[citation needed] In general, extra B vitamins are just flushed out of the system, although everyone's limit of absorption is different in regards to B complex vitamins, and no one knows how much is needed on an individual basis of these vitamins…"[25] The elderly and athletes may need to supplement their intake of B12 and other B vitamins due to problems in absorption and increased needs for energy production. Both type 1 and type 2 diabetics may also be advised to supplement thiamine based on high prevalence of low plasma thiamine concentration and increased thiamine clearance associated with diabetes.[26] Also, Vitamin B9 (folic acid) deficiency in early embryo development has been linked to neural tube defects. Thus, women planning to become pregnant are usually encouraged to increase daily dietary folic acid intake and/or take a supplement.[27] However, for "most typical consumers of energy supplements or drinks, B vitamins are nothing more than a 'gimmick'."[25]

Related nutrients

Many of the following substances have been referred to as vitamins because they were believed to be vitamins at one time. They are not considered vitamins anymore and the numbers that were assigned to them now form the "gaps" in the true series of B-complex vitamins described above (e.g. there is no vitamin B4). Some of them, though not essential to humans, are essential in the diets of other organisms; others have no known nutritional value and may even be toxic under certain conditions.

  • Vitamin B7: is also known as "vitamin I" of Centanni E. (1935)—also called "Enteral factor"—is a water and alcohol-soluble rice-bran factor that prevents digestive disturbance in pigeons. It governs the anatomical and functional integrity of the intestinal tract. Later found in yeast. Possible candidates for this substance are inositol, niacin (nicotinic acid), and biotin. Carnitine was also claimed to be a candidate but is not soluble in alcohol. Ref: Biochim, e terap. sper. 22:137 (April 30)1935 E. Centenni. Presse med. 51 No6 66-7 1943 R. Jacquot (on enteral B7 in Yeast) et al.
  • Vitamin B8: adenosine monophosphate, or alternately myo-inositol, is synthesized by the human body.[citation needed]
  • Vitamin B10: para-aminobenzoic acid (PABA)
  • Vitamin B11: pteryl-hepta-glutamic acid—chick growth factor, which is a form of folic acid. Later found to be one of five folates necessary for humans; also known as vitamin S or factor S.
  • Vitamin B13: orotic acid, now known not to be a vitamin.
  • Vitamin B14: cell proliferant, anti-anemia, rat growth factor, and antitumor pterin phosphate named by Earl R. Norris. Isolated from human urine at 0.33ppm (later in blood), but later abandoned by him as further evidence did not confirm this. He also claimed this was not xanthopterin.
  • Vitamin B15: pangamic acid
  • Vitamin B16: dimethylglycine (DMG)
  • Vitamin B17: nitrilosides, amygdalin or Laetrile. These substances are found in a number of seeds, sprouts, beans, tubers, and grains. While toxic in large quantities, proponents claim that it is effective in cancer treatment and prevention[29] despite a lack of accepted scientific evidence.
  • Vitamin B18:
  • Vitamin B19:
  • Vitamin B20: carnitine
  • Vitamin B21:
  • Vitamin B22: often claimed as an ingredient of Aloe vera extracts but also in many other foods. Claimed by one source to be vitamin B12b-δ.[citation needed]
  • Vitamin Bh: biotin
  • Vitamin Bm: "mouse factor": also used to designate inositol
  • Vitamin Bp: choline[dubious ] Choline is only required for survival of some mutants. Most commonly it is synthesized in vivo de novo.[30] May be added as supplement especially when methionine supply is limited[why?]

Note: B16, B17, B18, B19, B20, B21 & B22 do not appear to be animal factors but are claimed by some naturopaths as human therapeutic factors.[citation needed]

References

  1. ^ "Confronting Pancreatic Cancer". http://www.pancreatica.org. Retrieved 2008-02-08. 
  2. ^ Schernhammer, E., et al. (June 1, 2007). "Plasma Folate, Vitamin B6, Vitamin B12, and Homocysteine and Pancreatic Cancer Risk in Four Large Cohorts". Cancer Research 67 (11): 5553–60. doi:10.1158/0008-5472.CAN-06-4463. PMID 17545639. http://cancerres.aacrjournals.org/cgi/content/abstract/67/11/5553. Retrieved 2008-02-08. 
  3. ^ United Press International (June 1, 2007). "Pancreatic cancer risk cut by B6, B12". UPI.com. http://www.upi.com/Consumer_Health_Daily/Briefing/2007/06/01/pancreatic_cancer_risk_cut_by_b6_b12/3712/. Retrieved 2008-02-08. 
  4. ^ Vitamins, water soluble at FAQ.org
  5. ^ Shaw I, Rucklidge JJ, Hughes RN. (2010). "A Possible Biological Mechanism for the B Vitamins Altering Behaviour in Attention-Deficit/Hyperactivity Disorder". Pharm Med 24 (5): 289–294. http://adisonline.com/pharmaceuticalmedicine/Fulltext/2010/24050/A_Possible_Biological_Mechanism_for_the_B_Vitamins.3.aspx. 
  6. ^ a b National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed. (1998). "Chapter 4 - Thiamin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press. pp. 58–86. ISBN 0-309-06411-2. http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/58-86_150.pdf. Retrieved 2009-06-17. 
  7. ^ a b National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed. (1998). "Chapter 5 - Riboflavin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press. pp. 87–122. ISBN 0-309-06411-2. http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/87-122_150.pdf. Retrieved 2009-06-17. 
  8. ^ a b National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed. (1998). "Chapter 6 - Niacin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press. pp. 123–149. ISBN 0-309-06411-2. http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/123-149_150.pdf. Retrieved 2009-06-17. 
  9. ^ http://www.rxabbott.com/pdf/niaspan.pdf
  10. ^ a b National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed. (1998). "Chapter 7 - Vitamin B6". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press. pp. 150–195. ISBN 0-309-06411-2. http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/150-195_150.pdf. Retrieved 2009-06-17. 
  11. ^ a b National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed. (1998). "Chapter 8 - Folate". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press. pp. 196–305. ISBN 0-309-06411-2. http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/196-305_150.pdf. Retrieved 2009-06-17. 
  12. ^ a b National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed. (1998). "Chapter 9 - Vitamin B12". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press. pp. 346. ISBN 0-309-06411-2. http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/306-356_150.pdf. Retrieved 2010-09-23. 
  13. ^ Dupré, A; Albarel, N; Bonafe, JL; Christol, B; Lassere, J (1979). "Vitamin B-12 induced acnes". Cutis; cutaneous medicine for the practitioner 24 (2): 210–1. PMID 157854. 
  14. ^ Stipanuk, M.H. (2006). Biochemical, physiological, molecular aspects of human nutrition (2nd ed.). St Louis: Saunders Elsevier p.667
  15. ^ Winklera, C; B. Wirleitnera, K. Schroecksnadela, H. Schennachb and D. Fuchs (September 2005). "Beer down-regulates activated peripheral blood mononuclear cells in vitro". International Immunopharmacology 6 (3): 390–395. doi:10.1016/j.intimp.2005.09.002. PMID 16428074. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7N-4H6XNCT-1&_user=4423&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1170050114&_rerunOrigin=scholar.google&_acct=C000059605&_version=1&_urlVersion=0&_userid=4423&md5=ad33efbb2638c397f63aa8c4e2b202af. Retrieved 2010-01-18. 
  16. ^ Hoyumpa Jr, AM (1980). "Mechanisms of thiamin deficiency in chronic alcoholism". American Journal of Clinical Nutrition 33 (12): 2750–2761. PMID 6254354. http://www.ajcn.org/cgi/content/abstract/33/12/2750. Retrieved 2010-01-18. 
  17. ^ Leevy, Carroll M. (1982). "Thiamin deficiency and alcoholism". Annals of the New York Academy of Sciences 378 (Thiamin: Twenty Years of Progress): 316–326. doi:10.1111/j.1749-6632.1982.tb31206.x. http://www3.interscience.wiley.com/journal/119560210/abstract?CRETRY=1&SRETRY=0. Retrieved 2010-01-18. 
  18. ^ Pinto, J; Y P Huang, and R S Rivlin (May 1987). "Mechanisms underlying the differential effects of ethanol on the bioavailability of riboflavin and flavin adenine dinucleotide". Journal of Clinical Investigation 79 (5): 1343–1348. doi:10.1172/JCI112960. PMC 424383. PMID 3033022. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=424383. 
  19. ^ Spivak, JL; DL Jackson (June 1977). "Pellagra: an analysis of 18 patients and a review of the literature". The Johns Hopkins Medical Journal 140 (6): 295–309. PMID 864902. 
  20. ^ Said, HM; A Sharifian, A Bagherzadeh and D Mock (1990). "Chronic ethanol feeding and acute ethanol exposure in vitro: effect on intestinal transport of biotin". American Journal of Clinical Nutrition 52 (6): 1083–1086. PMID 2239786. http://www.ajcn.org/cgi/content/abstract/52/6/1083. Retrieved 2010-01-18. 
  21. ^ Halsted, Charles; Picciano, M.F., Stokstad, E.L.R. and Gregory, J.F. (eds) (1990). Intestinal absorption of dietary folates (in Folic acid metabolism in health and disease). New York, New York: Wiley-Liss. pp. 23–45. ISBN 0471567442. http://agris.fao.org/agris-search/search/display.do?f=1992/v1803/US9141384.xml;US9141384. 
  22. ^ Watson, Ronald; Watzl, Bernhard, eds. (September 1992). Nutrition and alcohol. CRC Press. pp. 16–18. ISBN 978-0849379338. 
  23. ^ Herbert, Victor (1 September 1998). "Vitamin B-12: Plant sources, requirements, and assay". Am. J. Clin. Nutr. 48 (3): 852–8. PMID 3046314. http://www.ajcn.org/cgi/reprint/48/3/852. Retrieved 2008-02-26. 
  24. ^ Vitamin B injections mentioned
  25. ^ a b c d e Chris Woolston (July 14, 2008). "B vitamins don't boost energy drinks' power". Los Angeles Times. http://www.latimes.com/features/health/la-he-skeptic14-2008jul14,0,3939169.story. Retrieved 2008-10-08. 
  26. ^ . doi:10.1007/s00125-007-0771-410.1007/s00125-007-0771-4. PMC 1998885. PMID 17676306. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1998885. 
  27. ^ . doi:10.1097/00001648-199505000-00005. PMID 7619926. 
  28. ^ Vera Reader (1930). "The assay of vitamin B4". Biochem J. 24 (6): 1827–31.. PMC 1254803. PMID 16744538. http://www.biochemj.org/bj/024/1827/0241827.pdf. 
  29. ^ Clark, Jim (September 2003). "Foods Containing B17". All Natural Cancer Therapy. Archived from the original on 2007-08-28. http://web.archive.org/web/20070828221422/http://home.bluegrass.net/~jclark/b17_dosage.htm. Retrieved 2007-07-07. 
  30. ^ Stecol JA (1958). "Biosynthesis of Choline and Betaine". Am J Clin Nutr. 6 (3): 200–15.. PMID 13533306. http://www.ajcn.org/cgi/reprint/6/3/200.pdf. 

 
 

 

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American Heritage Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Oxford Dictionary of Chemistry. A Dictionary of Chemistry. Sixth Edition. Copyright © Market House Books Ltd, 2008. All rights reserved.  Read more
Britannica Concise Encyclopedia. Britannica Concise Encyclopedia. © 1994-2012 Encyclopædia Britannica, Inc. All rights reserved.  Read more
Oxford Food & Nutrition Dictionary. A Dictionary of Food and Nutrition. Copyright © 1995, 2003, 2005 by A. E. Bender and D. A. Bender. All rights reserved.  Read more
 Oxford A-Z of Medicinal Drugs. Market University Press. © 2000, 2003, 2010 An A-Z of Medicinal Drugs. All rights reserved.  Read more
Wikipedia on Answers.com. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article B vitamins Read more

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