Yersinia enterocolitica is a species of gram-negative coccobacillus-shaped bacterium, belonging to the family Enterobacteriaceae. Primarily a zoonotic disease (cattle, deer,
pigs, and birds), animals which recover frequently become asymptomatic carriers of the disease.[1]
Pathogenesis
Acute infections
Acute Y. enterocolitica infections produce severe diarrhea in humans, along with Peyer's patch necrosis, chronic lymphadenopathy, and hepatic or
splenic abscesses. Additional symptoms may include entero-colitis, fever, mesenteric adenitis, erythema nodosum and acute terminal ileitis, which may be confused with appendicitis or Crohn's disease. See yersiniosis for further details.
Treatment
Treatment of Y. enterocolitica infections requires aggressive antibiotic therapy, typically involving a combination of
chloramphenicol, ampicillin, and polymyxin.[1]
Long-term effects
Y. enterocolitica infections are sometimes followed by chronic inflammatory diseases such as arthritis.[2]
Y. enterocolitica seems to be associated with autoimmune Graves-Basedow
thyroiditis.[3] Whilst indirect evidence exists, direct causative evidence is limited,[4] and Y. enterocolitica is
probably not a major cause of this disease, but may contribute to the development of thyroid autoimmunity arising for other
reasons in genetically susceptible individuals.[5] It has
also been suggested that Y. enterocolitica infection is not the cause of auto-immune
thyroid disease, but rather is only an associated condition; with both having a
shared inherited susceptibility.[6] More recently the role
for Y. enterocolitica has been disputed.[7]
External Links
Footnotes
- ^ a b Collins FM (1996).
Pasteurella, Yersinia, and Francisella. In: Barron's Medical Microbiology (Barron S et al, eds.), 4th
ed., Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
- ^ Ryan KJ; Ray CG
(editors) (2004). Sherris Medical Microbiology, 4th ed., McGraw Hill. ISBN 0-8385-8529-9.
- ^ Benvenga S,
Santarpia L, Trimarchi F, Guarneri F (2006). "Human Thyroid Autoantigens and Proteins of Yersinia and Borrelia
Share Amino Acid Sequence Homology That Includes Binding Motifs to HLA-DR Molecules and T-Cell Receptor". Thyroid
16 (3): 225-236. PubMed.
- ^ Tomer Y,
Davies T (1993). "Infection,
thyroid disease, and autoimmunity." (PDF). Endocr Rev 14 (1): 107-20. PMID 8491150.
- ^ Toivanen P, Toivanen A (1994). "Does
Yersinia induce autoimmunity?". Int Arch Allergy Immunol 104 (2): 107-11. PMID 8199453.
- ^ Strieder T, Wenzel B, Prummel M, Tijssen J,
Wiersinga W (2003). "Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in
relatives of patients with autoimmune thyroid disease.". Clin Exp Immunol 132 (2): 278-82. PMID
12699417.
- ^ Hansen P, Wenzel B, Brix T, Hegedüs L
(2006). "Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin
study.". Clin Exp Immunol 146 (1): 32-8. PMID 16968395.
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