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Neuraminidase inhibitors such as oseltamivir and zanamivir are found in the vaccine, and are used to block the neuraminidase protein in the viruses from working and prevent it from reproducing.

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Neuraminidase inhibitors such as oseltamivir and zanamivir are found in the vaccine, and are used to block the neuraminidase protein in the viruses from working and prevent it from reproducing.

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It is a protein on the influenza virus that is thought to help the virus escape from the cell after it replicates. Zanamivir and oseltamivir are drugs that inhibit this action and thus trap virus particles within an infected cell.

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It is an antiviral medication prescribed to treat certain viral diseases. However, it is not one of the antiviral medications recommended for use for the A-H1N1/09 pandemic swine flu virus. The two antiviral medicines that have shown to be effective and recommended by the Centers for Disease Control and Prevention (CDC) are oseltamivir and zanamivir. This is what the CDC says:
At this time, treatment with oseltamivir (trade name Tamiflu®) or zanamivir (trade name Relenza®) is recommended for all people with suspected or confirmed influenza who require hospitalization.

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Most antiviral drugs must be started within 40 - 48 hours of the first signs of the flu for most efficacy. These drugs reduce the severity and duration of the symptoms, but do not actually "cure" the flu, that job must be done by your immune system.

There are two types of of antiviral agents, the first one is the adamantanes, such as amantadine (Symmetrel®) and rimantadine (Flumadine®). Adamantanes are useful only for influenza type A infections. The second type of antiviral agents are the neuraminidase inhibitors, such as zanamivir (Relenza®) and oseltamivir (Tamiflu®, 1999).


Approximately 80% of the circulating strains of flu viruses typical in a flu season are influenza type A virus H1N1. These types can be treated with adamantanes and zanamivir, but are resistant and cannot be treated with oseltamavir. Sometimes many of the circulating strains can be resistant to antivirals, but usually one type will work. The Centers for Disease Control and Prevention (CDC) provides information each year about the expected strains of flu coming in the next season and which antiviral drugs will be best to treat them.


Influenza type A virus H3N2 strains can be treated with oseltamavir and zanamivir, but are resistant to adamantanes.


As for influenza type B strains, they can be treated with oseltamavir, zanamivir; but are resistant, and cannot be treated with adamantanes.


In addition, for unvaccinated patients the recommended drug for influenza B exposure is oseltamivir, and the recommended drug for influenza A exposure or unknown subtype are zanamivir OR oseltamivir + rimantadine.

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Tamiflu (Oseltamivir) and Relenza (Zanamivir) are the two antiviral medications that are effective for the A-H1N1/09 virus. The Centers for Disease Control and Prevention information on the side effects of these medicines is:


Tamiflu

The side effects reported most often in those people who took this drug were gastrointestinal (i.e., nausea and vomiting). Nausea and vomiting may be less severe if oseltamivir is taken with food.

Relenza

This drug is inhaled and can cause side effects, especially in those with asthma or other chronic lung disease. Decreased respiratory function and bronchospasm have been reported with use of zanamivir. Zanamivir is generally not recommended for use in persons with underlying lung disease such as asthma and chronic obstructive pulmonary disease. Other side effects reported by less than 5% of those who have used this drug are diarrhea, nausea, sinusitis, nasal infections, bronchitis, cough, headache, and dizziness.

[More on side effects of these anti-viral medications:]

Reported side effects of oseltamivir are nausea and vomiting. Among children treated with oseltamivir in clinical studies, 14% had vomiting, compared with 8.5% of children getting a "placebo." (A placebo is an inactive substance that looks the same as, and is given in the same way as, a drug in a clinical trial.) Nausea and vomiting might be less severe if oseltamivir is taken with food. In addition, there have been reports of self-injury or delirium among persons with influenza who take oseltamivir. Most of these reports have been in teenagers from Japan, and it is still not certain whether oseltamivir or the influenza virus was responsible for these behavior changes. The U.S. Food and Drug Administration advises that people taking either of the two medications recommended for influenza (oseltamivir and zanamivir) be monitored closely for abnormal behavior.

Side effects from zanamivir have been reported in fewer than 5% of people participating in clinical trials and have been reported at the same rate in people receiving zanamivir as those being given a "placebo." Reported side effects have included diarrhea, nausea, sinusitis, nasal signs and symptoms, bronchitis, cough, headache, dizziness, and ear, nose, and throat infections. Also, zanamivir should not be used in people with underlying respiratory disease, including asthma.



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