Yes, when both are referring to people.
Destitute means impoverished, broke, or extremely poor. The opposite would be wealthy, well-to-do, or rich.
Poor, unsuccessful, failing, or destitute. Those words mean wealthy.
poor
The area was destitute and bare.
Destitute is an adjective.
Wealthy and arrogant are not antonyms(opposites) Arrogant is and adjective that describes somone as someone who thinks that they are more superior and better than everyone else. While wealthy means to be rich. These too words are not antonyms.
He had reached such a state of destitution that he drank from dirty puddles and ate What_is_a_sentence_with_destitution_in_itfrom waste bins.
wealthyaffluentrich
The noun form of destitute is destitution.
Sisters of the Destitute was created in 1927.
Palestine is a poor country. Of course, it is not destitute like most African countries, but it is on a similar economic footing as Egypt or Jordan.
The family of Pope Francis was far from wealthy but were not destitute. I suppose that the term 'lower middle class' would be appropriate.
She felt bad for the lady on the street that was destitute.