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NO they are not. It may be a fun idea for a fanfiction but Pein and Sakura are not brother and Sister, if they were because you are either born with Rinnegan or earn it from many years of eteranl Mangekyo Sharingan, she would also most likely have the Rinnegan, or at least stick around Pein.

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Q: Are sakura and pein brother and sister?
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