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To some degree this depends upon the type of worm and the breed of the puppy. There are OTC deworming medications available for puppies that rely on pyrantel pamoate which are quite safe but are only effective against roundworms and hookworms. There are other OTC deworming medications that rely on ivermectin, but these can be dangerous in collie-type breeds. Also, there are currently no effective OTC medications for tapeworms or whipworms.

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