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The anti-depressants Effexor XR (venlafaxine) as well as it's sister Pristiq (desvenlafaxine) are both capable of causing false PCP positives on urine screens. More common OTC drugs that could be to blame include Ibprofen, which is widely known to metabolize into your urine as Phencyclidine (the main chemical in PCP). Phenhydramine, and dextromethorphan (cough syrup) also work the same way. All of which are in most OTC cold/allergy medications.

I work with DISA, Inc. which is a drug screening center for employment. In towns where PCP as a street drug is very uncommon, we often dismiss the positive testing of PCP as a false positive.

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Q: Are there any other drugs that yield the same metabolites as PCP which will cause a false positive on a urine drug test?
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