Are there any published data for Cefixime and clavulanic acid?

Answer 1

Yes, we have complete data for our new brand Sifixim - CV (Combination of Cefixime with Clavulanic acid).In which we have given the complete rational of combination, some important points of the same are as follows:-

Journal of Antimicrob Chemotherapy - "Resistance to cephalosporins due to Class A beta-lactamases was reversed by clavulanate."

Classical TEM and SHV beta-lactamases is exceptional for a cephalosporin, but was reversible with clavulanate,

Clin Microbiol Infect. 2008 - Clavulanate is a highly effective inhibitor of extended-spectrum beta-lactamases (ESBLs) in detection tests, but the commercial amoxycillin-clavulanate and ticarcillin-clavulanate combinations have borderline activity, at best, against most ESBL producers

Combinations of clavulanate with modern anti-methicillin-resistant Staphylococcus aureus cephalosporins also deserve investigation, as these compounds remain labile to ESBLs.

• HA-MRSA Since HA-MRSA strains are multidrug-resistant organisms (MDRO), final therapy should be guided by results of susceptibility testing from cultures obtained before the initiation of empirical therapy.11,13,15,25 For initial empirical antibiotic therapy for HA-MRSA, Grayson25 has suggested vancomycin, , 3rd / 4th generation cephalosporins plus clavulanate, linezolid, daptomycin or rifampin plus trimethoprim-sulfamethoxazole.

For further detail you can contact the undersigned

Amit Vyas

Marketing Manager

Svizera Healthcare Ltd.

amitvyas@svizerahealth.com