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Can polymerase catch and correct every reptication error?
Yes. Initially, DNA replication makes 1 mistake in a 100,000. Like spell check, DNA polymerase comes in and removes errors in base pairs and correct them by adding the right ones. After DNA polymerase checks the new strand for errors, the end result is 1 mistake in a billion. If this didn't occur, mutations would surely take place in out body.
Which of the following would cause an error in DNA replication?
An error in DNA replication can be caused by factors such as DNA polymerase mistakes, damage to the DNA template, or interference from environmental factors like UV radiation or chemicals. Mutations in the DNA sequence or insufficient nucleotide precursors can also lead to errors in DNA replication.
Which help prevents errors in DNA replication?
each base can can attach to only one other type of base.
What helps lower the error rate in DNA replication to 1 in 1 billion nucleotides?
They are the DNA repair system, which lowers the error. They are broadly of two types- i) direct RS ii) extensive RS. In direct RS, only single faulty nucleotide is replaced, and in extensive, a part of DNA is replaced!
What is the mRNA sequence of a-t-t-c-g-a-c-c-t-a-c-g?
A DNA polymerase made an error during the replication of an important gene region of DNA. None of the DNA repair enzymes detected or repaired the damage. A portion of the DNA strand with the error is AATTCCGACTCCTATGG
How often does DNA polymerase match bases incorrectly?
DNA polymerase has an error rate of approximately 1 in every 10^7-10^8 nucleotides incorporated. This means that it matches bases incorrectly about once in every 10 million to 100 million nucleotides during DNA replication.
What causes an error in DNA replications?
DNA polymerase pairing A with G
Why would DNA polymerase drugs be useful against cancer?
Hall mark of cancer is genomic instability, in form of mutations or chromosomal aberrations. Genomic instability is failure to maintain genome stable, which was maintained by using proper replication and repair,any imbalance in this can lead to instability. There are many error prone DNA polymerases which are error prone which were evolved to keep cell alive by continuing DNA replication when extensive DNA damage happened. Many cancers have differential expression of various DNA polymerases Example: Up regulation of DNA polymerase theta in Breast cancer
How errors in DNA replication are fixed?
Errors in DNA replication are fixed through DNA repair mechanisms. Cells have various repair pathways, such as base excision repair, nucleotide excision repair, and mismatch repair, which correct different types of DNA damage. These repair processes involve identifying the error, removing the incorrect DNA sequence, and accurately inserting the correct nucleotides.
Why is the replication process is a source of few mutations?
Some mutations are due to errors in DNA replication. During the replication process, DNA polymerase chooses complementary nucleotide triphosphates from the cellular pool. Then the nucleotide triphosphate is converted to a nucleotide monophosphate and aligned with the template nucleotide. A mismatched nucleotide slips through this selection process only onece per 100,000 base pairs at most. The mismatched nucleotide causes a pause in replication, during which it is excised from the daughter strand and replaced with the correct nucleotide. After this so-called proofreading has occurred, the error rate is only one per 1 billion base pairs.
What you an error called while copying DNA?
One common error is a mismatched base pair incorporation, where an incorrect nucleotide is added during DNA replication. This can lead to mutations in the copied DNA sequence. Other errors include deletions, insertions, and frameshift mutations.
What type of error provides an incorrect result but is not a syntax or run time error?
A logic error.
