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Absolutely not, for several reasons:

1. The amount of hair on most people's thighs precludes obtaining a good attachment of the patch - unless you like shaving your legs and having patch marks on them.

2. The primary reason is that the patch must be applied on the upper torso to ensure good dosage regulation by the heart. Blood flow is further from the heart in the lower extremities, and drug regulation isn't as good.

3. One of the main problems with patch application (I always use my biceps) is that you need a patch of skin that doesn't flex readily with body movement, or you risk the patch adhesive losing adhesion due to skin flexing. Our leg skin flexes considerably during the day.

Terminal cancer patients using several (more than 2) patches typically will have them applied to their back.

In my case, when I was using 2 100mcg patches, I'd overlap the application time, but still used both biceps. While the literature tells you that you shouldn't use the same spot all the time, the reality is that you can, as long as you clean the area and let the skin breathe. During times when I only need one patch, I'd just switch biceps; when using 2, I'd take one off, let the skin breathe for a few hours, then apply a new patch, then do the same on the other patch. This way you don't deal any withdrawal symptoms, as it usually takes a while for you to start feeling it.

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Q: Can Fentanyl patches be applied on the thigh?
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