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PPI (Proton Pump Inhibitors) work to reduce the production of stomach acid via a different mechanism at the cellular level than H2 inhibitors. The current guidelines recommend either one or the other and therapy lasting no longer than 2 weeks without consulting a physician.

If the person asking the question feels that using both medication is warranted because of the severity of symptoms, or have tried both separately and found them ineffective for relieving symptoms, the most beneficial route would be to see a primary care doctor or other healthcare professional for a recommendation about how to proceed.

with all of that stated; they can be used together but, the user runs the risk of decreasing stomach acid to a point where it no longer offers a protective function and may cause untoward side effects.

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Q: Can PPIs be used with H2 inhibitors?
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